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Fig. 4 | BMC Pediatrics

Fig. 4

From: Clinical and genetic analysis of a case with centronuclear myopathy caused by SPEG gene mutation: a case report and literature review

Fig. 4

Histological examination of the patient’s muscle biopsies: a The acid reaction series of ATPase showed checkerboard distribution of myofibers, and the pathology of type I myofibers was dominant. There are two types of atrophic myofibers, mainly type I. The diameter of type I myofiber is generally smaller than that of type II myofiber. b The alkaline reaction series of ATPase confirmed the abovementioned distribution characteristics of myofibers. Slightly atrophied-type II fiber is 15–25 μm in diameter. c HE staining shows that the nuclei of some myofibers are located in the center of the cell. d NADH1 staining showed that the center of some myofibers was slightly darker

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