| Crude OR | Adjusted model Ia | Adjusted model IIb |
---|---|---|---|
Preconceptional | |||
 3 months before conception | 1.40 (1.22, 1.61)*** | 1.98 (1.67, 2.34)*** | 1.15 (0.91, 1.46) |
 1 year before conception | 1.86 (1.48, 2.32)*** | 10.21 (7.08, 14.71)*** | 2.53 (1.56, 4.10)*** |
Prenatal | |||
 1st trimester | 1.72 (1.50, 1.97)*** | 2.30 (1.94,2.72)*** | 1.63 (1.32, 2.00)*** |
 2nd trimester | 1.99 (1.71, 2.33)*** | 2.55 (2.12,3.07)*** | 1.43 (1.12, 1.81)** |
 3rd trimester | 1.88 (1.62, 2.18)*** | 2.29 (1.91,2.73)*** | 1.20 (0.96, 1.51) |
 Entire pregnancy | 4.45 (3.52, 5.6)*** | 8.36 (6.21,11.27)*** | 1.85 (1.24, 2.76)** |