Table 1 Different HB staging criteria for children with the disease
Stage | Phasing criteria |
|---|---|
The PRETEXT preoperative typing system | |
Stage I | Tumor confined to 1 liver segment, no tumor invasion in 3 adjacent liver segments |
Stage II | The tumor involved 2 liver segments and the other 2 adjacent liver segments were not invaded by the tumor. |
Stage III | The tumor involves 2 liver segments and the other 2 non-contiguous liver segments are not involved; or the tumor involves 3 liver segments. |
Stage IV | The tumor involved 4 liver segments. |
Annotation factors | P (portal invasion) |
V (hepatic vein/vessel invasion) | |
F (multifocality) | |
E (extrahepatic tumor extension) | |
R (tumor rupture) | |
M (distant metastasis) | |
The postoperative COG Evans staging system | |
Stage I a | Complete resection of the tumor, histopathologic type of simple fetal type |
Stage I b | Complete resection of tumor, histopathological types other than simple fetal type |
Stage II | Tumor largely resected, with microscopic remnants |
Stage III | Tumor with visual remnants, or basic resection with positive lymph nodes, or tumor rupture or peritoneal hemorrhage |
Stage IV | Occurrence of distant metastases at diagnosis, regardless of complete resection of the primary lesion |