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Table 4 Alterations identified at birth in newborns reported with CS by treatment scheme, Fortaleza, Ceará, 2015

From: Treatment administered to newborns with congenital syphilis during a penicillin shortage in 2015, Fortaleza, Brazil

Variables

Newborn Treatment

p value

Standard schemea

Other schemes

n

%

n

%

Serum VDRL result (n = 467)

    

0.501

 Reactive

168

45.8

199

54.2

 

 Non-reactive

42

42.0

58

58.0

 

VDRL titration (n = 367)

    

0.021

  ≤ 1:8

136

43.3

178

56.7

 

  ≥ 1:16

32

60.4

21

39.6

 

CSF alteration (n = 292)

    

0.174

 Yes

13

50.0

13

50.0

 

 No

97

36.5

169

63.5

 

Long bone radiography alteration (n = 139)

    

1.000b

 Yes

3

30.0

7

70.0

 

 No

46

35.7

83

64.3

 

Blood count alteration (n = 362)

    

0.155

 Yes

61

38.4

98

61.6

 

 No

93

45.8

110

54.2

 

Showed clinical manifestation at birth (n = 456)

    

0.003

 Yes

105

52.8

94

47.2

 

 No

100

38.9

157

61.1

 

Preterm birth (n = 469)

    

< 0.001

 Yes

43

66.2

22

33.8

 

 No

168

41.6

236

58.4

 

Low birth weight (n = 469)

    

0.010

 Yes

50

57.5

37

42.5

 

 No

161

42.1

221

57.9

 

Jaundice with phototherapy (n = 454)

    

0.019

 Yes

63

54.3

53

45.7

 

 No

141

41.7

197

58.3

 

Hepatomegaly (n = 456)

    

0.045

 Yes

10

71.4

4

28.6

 

 No

196

44.3

246

55.7

 

Splenomegaly (n = 456)

    

0.477b

 Yes

5

62.5

3

37.5

 

 No

201

44.9

247

55.1

 

Skin lesions (n = 456)

    

0.353b

 Yes

6

60.0

4

40.0

 

 No

195

44.3

245

55.7

 
  1. a Considered when using any of the MoH-recommended treatment schemes: 1) aqueous crystalline penicillin G 50,000 IU/kg/dose, intravenously, every 12 h (in the first 7 days of life) and every 8 h (after 7 days of life), for 10 days; 2) procaine penicillin G 50,000 IU/kg, single daily dose, intramuscularly for 10 days; 3) benzathine penicillin G, a single dose of 50,000 IU/kg intramuscularly
  2. b Fisher’s Exact test