Skip to main content

Table 3 Clinical and endocrinological characteristics at diagnosis in 8 patients with clinical MODY

From: Etiologic distribution and clinical characteristics of pediatric diabetes in 276 children and adolescents with diabetes at a single academic center

Subject No. Molecular defect Sex Age at diagnosis (year) Number of generations with DM BMI HbA1c,% Serum C-peptide, ng/mL (0.48–3.3) Presence of
β-cell antibodies (Ab)
Microangiopathy
GAD Ab, U/mL (0–1) Insulin Ab, % (0–7)
1 HNF1B c.443C > T (p.S148L) F 14.6 0 19 6 0.58 NA NA Nephropathy
2 ND F 11.8 3 21.8 8.7 4.4 0.1 4.4 None
3 ND M 13 3 17.7 14.4 0.37 < 0.1 NA None
4 ND M 18.5 0 18.4 7.7 1.4 1.1 6.6 None
5 ND F 12.3 2 19.2 12.9 1.1 0.94 6.3 None
6 ND M 12.3 3 20.4 9.5 2.4 0.41 6 None
7 ND M 15.7 2 18 11.5 1.8 0.28 5.7 None
8 ND F 9.4 3 19.6 6.7 5.7 1.1 5.1 None
  1. GAD Glutamic acid decarboxylase, ND Not detected