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Table 3 Interaction between PRS and moderate to vigorous physical activity on TBBMD and LSBMD 1,2,3

From: Genetic variants and physical activity interact to affect bone density in Hispanic children

Marker

β_G4

Pvalue_G

β_Interaction5

Pvalue_Interaction

Polygenic Risk Scores

 TBBMD

  TBBMD_PRS, cat

−0.5

5.9 × 10−5

0.37

0.0047

 LSBMD

  TBBMD_PRS, cat

−0.45

1.8 × 10−5

0.36

0.0011

Individual SNPs

 TBBMD

  rs10953178

−0.29

7.6 × 10−4

0.22

0.046

  rs914153

−0.21

5.5 × 10−3

0.2

0.028

 LSBMD

  rs452369

−0.38

5.6 × 10−6

0.24

0.038

  rs10953178

−0.26

1.5 × 10− 3

0.27

0.0074

  rs914153

−0.23

6.2 × 10−4

0.24

0.0058

  1. 1 Only results with statistically significant interactions are shown (p value for interaction< 0.05)
  2. 2 Adjusted for age, sex, BMI Z-score, and puberty stage
  3. 3 PRS Polygenic Risk Score, LSBMD lumbar spine bone mineral density, TBBMD total body bone mineral density; TBBMD_PRS, cat TBBMD unweighted PRS, categorized by median (> = median vs below)
  4. 4 β_G, beta coefficients for main effects of PRS
  5. 5 β_Interaction, beta coefficients for interaction effects between PRS and MVPA
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BMC Pediatrics

ISSN: 1471-2431

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