Table 3 Clinical and biochemical parameters according to the presence of osteoporosis
From: Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease
| Spine BMD ≤ -2 SDS (n = 25) | Spine BMD > -2 SDS (n = 94) | P value | |
|---|---|---|---|
| Sex (male:female) | 13:12 | 66:28 | |
| Age at diagnosis, years | 14.3 ± 1.5 | 13.5 ± 2.1 | 0.057 |
| PCDAI | 36.56 ± 20.16 | 31.82 ± 17.80 | 0.410 |
| Delayed puberty | 8/25 | 3/94 | < 0.001 |
| Height-SDS at diagnosis | -1.47 ± 1.11 | -0.11 ± 0.90 | < 0.001 |
| Weight-SDS at diagnosis | -2.40 ± 1.45 | -0.99 ± 1.23 | < 0.001 |
| BMI-SDS at diagnosis | -2.07 ± 1.36 | -1.19 ± 1.35 | 0.009 |
| Calcium, mg/dL | 8.67 ± 0.57 | 8.94 ± 0.46 | 0.082 |
| Phosphorus, mg/dL | 5.07 ± 0.53 | 4.28 ± 0.75 | 0.053 |
| Alkaline phosphatase, IU/L | 111.56 ± 38.04 | 124.65 ± 46.64 | 0.268 |
| IGF-1 SDS | -1.50 ± 1.46 | -1.00 ± 1.21 | 0.169 |
| IGFBP-3 SDS | -6.64 ± 21.53 | -1.21 ± 1.21 | 0.102 |
| TSH, µIU/mL | 2.40 ± 1.25 | 2.04 ± 1.39 | 0.222 |
| Free T4, ng/dL | 1.37 ± 0.15 | 1.40 ± 0.20 | 0.608 |
| LH, IU/L | 2.19 ± 2.04 | 2.71 ± 1.58 | 0.088 |
| FSH, IU/L | 4.18 ± 2.79 | 2.90 ± 2.04 | 0.098 |
| Estradiol, pg/mL | 17.34 ± 11.35 | 12.93 ± 3.81 | 0.657 |
| Testosterone, ng/mL | 1.71 ± 1.69 | 2.54 ± 2.16 | 0.323 |
| 25(OH)D3, ng/mL | 14.01 ± 5.71 | 14.26 ± 6.52 | 0.874 |
| Lumbar BMD Z-score | -2.34 ± 0.93 | -0.39 ± 1.07 | < 0.001 |