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Table 3 Clinical and biochemical parameters according to the presence of osteoporosis

From: Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease

 

Spine BMD ≤ -2 SDS (n = 25)

Spine BMD > -2 SDS (n = 94)

P value

Sex (male:female)

13:12

66:28

 

Age at diagnosis, years

14.3 ± 1.5

13.5 ± 2.1

0.057

PCDAI

36.56 ± 20.16

31.82 ± 17.80

0.410

Delayed puberty

8/25

3/94

< 0.001

Height-SDS at diagnosis

-1.47 ± 1.11

-0.11 ± 0.90

< 0.001

Weight-SDS at diagnosis

-2.40 ± 1.45

-0.99 ± 1.23

< 0.001

BMI-SDS at diagnosis

-2.07 ± 1.36

-1.19 ± 1.35

0.009

Calcium, mg/dL

8.67 ± 0.57

8.94 ± 0.46

0.082

Phosphorus, mg/dL

5.07 ± 0.53

4.28 ± 0.75

0.053

Alkaline phosphatase, IU/L

111.56 ± 38.04

124.65 ± 46.64

0.268

IGF-1 SDS

-1.50 ± 1.46

-1.00 ± 1.21

0.169

IGFBP-3 SDS

-6.64 ± 21.53

-1.21 ± 1.21

0.102

TSH, µIU/mL

2.40 ± 1.25

2.04 ± 1.39

0.222

Free T4, ng/dL

1.37 ± 0.15

1.40 ± 0.20

0.608

LH, IU/L

2.19 ± 2.04

2.71 ± 1.58

0.088

FSH, IU/L

4.18 ± 2.79

2.90 ± 2.04

0.098

Estradiol, pg/mL

17.34 ± 11.35

12.93 ± 3.81

0.657

Testosterone, ng/mL

1.71 ± 1.69

2.54 ± 2.16

0.323

25(OH)D3, ng/mL

14.01 ± 5.71

14.26 ± 6.52

0.874

Lumbar BMD Z-score

-2.34 ± 0.93

-0.39 ± 1.07

< 0.001

  1. BMD Bone mineral density, PCDAI Pediatric Crohn disease activity index, BMI Body mass index, IGF-1 Insulin-like growth factor-1, IGFBP-3 Insulin-like growth factor binding protein-3, TSH Thyroid stimulating hormone, LH Luteinizing hormone, FSH Follicle stimulating hormone, 25(OH)D3 25-hydroxyvitamin D3