Table 2 Clinical and biochemical parameters according to PCDAI scores
From: Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease
|
PCDAI < 30 Inactive/mild (n = 41) |
PCDAI ≥ 30 Moderate/Severe (n = 47) | P value | |
|---|---|---|---|
| Age at diagnosis, years | 13.5 ± 1.9 | 13.6 ± 2.7 | 0.934 |
| Sex (Male:Female) | 32:9 | 28:19 | |
| PCDAI score | 15.85 ± 7.96 | 45.80 ± 11.23 | < 0.001 |
| Short stature | 4/41 | 3/47 | 0.700 |
| Height-SDS | -0.18 ± 1.08 | -0.50 ± 0.97 | 0.156 |
| Weight-SDS | -0.50 ± 1.17 | -1.69 ± 1.32 | < 0.001 |
| BMI-SDS | -0.56 ± 1.31 | -1.79 ± 1.30 | < 0.001 |
| IGF-1 SDS | -0.35 ± 1.30 | -1.96 ± 1.17 | < 0.001 |
| IGFBP-3 SDS | -1.48 ± 1.31 | -4.63 ± 18.41 | 0.577 |
| BA/CA ratio | 0.85 ± 0.11 | 1.01 ± 0.11 | 0.034 |
| Delayed puberty | 3/41 | 3/47 | 1.000 |
| LH, IU/L | 2.88 ± 1.28 | 2.16 ± 1.66 | 0.104 |
| FSH, IU/L | 3.01 ± 1.51 | 2.12 ± 1.48 | 0.416 |
| Estradiol, pg/mL (Female) | 12.99 ± 3.19 | 15.21 ± 8.99 | 0.473 |
| Testosterone, ng/mL (Male) | 2.70 ± 2.14 | 1.32 ± 1.53 | 0.034 |
| TSH, µIU/mL | 2.12 ± 1.11 | 2.02 ± 1.32 | 0.784 |
| Free T4, ng/dL | 1.28 ± 0.13 | 1.41 ± 0.20 | 0.010 |
| 25(OH)D3, ng/mL | 14.23 ± 6.77 | 15.97 ± 6.52 | 0.253 |
| Osteoporosis | 7/38 | 9/46 | 0.813 |
| Lumbar BMD Z-score | -0.55 ± 1.39 | -0.84 ± 1.31 | 0.321 |