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Table 2 Clinical and biochemical parameters according to PCDAI scores

From: Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease

 

PCDAI < 30

Inactive/mild (n = 41)

PCDAI ≥ 30

Moderate/Severe (n = 47)

P value

Age at diagnosis, years

13.5 ± 1.9

13.6 ± 2.7

0.934

Sex (Male:Female)

32:9

28:19

 

PCDAI score

15.85 ± 7.96

45.80 ± 11.23

< 0.001

Short stature

4/41

3/47

0.700

Height-SDS

-0.18 ± 1.08

-0.50 ± 0.97

0.156

Weight-SDS

-0.50 ± 1.17

-1.69 ± 1.32

< 0.001

BMI-SDS

-0.56 ± 1.31

-1.79 ± 1.30

< 0.001

IGF-1 SDS

-0.35 ± 1.30

-1.96 ± 1.17

< 0.001

IGFBP-3 SDS

-1.48 ± 1.31

-4.63 ± 18.41

0.577

BA/CA ratio

0.85 ± 0.11

1.01 ± 0.11

0.034

Delayed puberty

3/41

3/47

1.000

LH, IU/L

2.88 ± 1.28

2.16 ± 1.66

0.104

FSH, IU/L

3.01 ± 1.51

2.12 ± 1.48

0.416

Estradiol, pg/mL (Female)

12.99 ± 3.19

15.21 ± 8.99

0.473

Testosterone, ng/mL (Male)

2.70 ± 2.14

1.32 ± 1.53

0.034

TSH, µIU/mL

2.12 ± 1.11

2.02 ± 1.32

0.784

Free T4, ng/dL

1.28 ± 0.13

1.41 ± 0.20

0.010

25(OH)D3, ng/mL

14.23 ± 6.77

15.97 ± 6.52

0.253

Osteoporosis

7/38

9/46

0.813

Lumbar BMD Z-score

-0.55 ± 1.39

-0.84 ± 1.31

0.321

  1. PCDAI Pediatric Crohn disease activity index, IGF-1 Insulin-like growth factor-1, IGFBP-3 Insulin-like growth factor binding protein-3, BA Bone age, CA Chronological age, LH Luteinizing hormone, FSH Follicle stimulating hormone, TSH  Thyroid stimulating hormone, 25(OH)D3 25-hydroxyvitamin D3