Table 4 The effect of valproic acid on bone mineral density in epileptic children
Author | Year | Testing method | Testing Equipment | Bone mineral density (Mean ± standard deviation) | |||||
|---|---|---|---|---|---|---|---|---|---|
Cases (N) | Vertebral (gm/cm2) | Femur (gm/cm2) | |||||||
Valproic acid | Control | Valproic acid | Control | Valproic acid | Control | ||||
Akin R [11] | 1998 | DXA | DXA Norland (Fort Atkinson, WI) XR-36 densitometer | 25 | 26 | 0.574 ± 0.02 | 0.568 ± 0.02 | – | – |
Kafali G [17] | 1999 | DXA | DEXA, QDR 4500 W Acclaim,Hologic | 19 | 57 | 0.517 ± 0.07 | 0.548 ± 0.07 | – | – |
Erbayat Altay E [14] | 2000 | DXA | DXA Norland (Fort Atkinson, WI) XR-36 densitometer | 15 | 22 | 0.596 ± 0.09 | 0.624 ± 0.08 | 0.66 ± 0.08 | 0.72 ± 0.07 |
Oner N [19] | 2004 | DEXA | Norland XR-36 analyzer, Norland Medical System, USA | 33 | 33 | 0.56 ± 0.2 | 0.57 ± 0.1 | 0.61 ± 0.2 | 0.69 ± 0.1 |
Ecevit C [16] | 2004 | DXA | XR-36, Norland, Hologic (Medical Equipment Company, Minster, OH) | 16 | 31 | – | – | 0.67 ± 0.08 | 0.73 ± 0.1 |
Kumandas S [18] | 2006 | DEXA | Hologic QDR 4500 Elite DEXA (USA) | 33 | 22 | 0.60 ± 0.09 | 0.65 ± 0.09 | – | – |
Babayigit A [13] | 2006 | DXA | Hologic QDR 4500 W bone densitometer | 31 | 30 | 0.665 ± 0.20 | 0.807 ± 0.13 | – | – |
Aksoy A [12] | 2011 | DXA | QDR-2000/W densitometer (Hologic, Waltham, MA, USA) | 53 | 50 | 0.58 ± 0.08 | 0.61 ± 0.08 | – | – |
Serin HM [22] | 2015 | DXA | Discovery Xi, Hologic | 28 | 20 | 0.58 ± 0.13 | 0.53 ± 0.13 | 0.6 ± 0.13 | 0.58 ± 0.13 |
Hasaneen B [7] | 2017 | Dual photon X-ray absorptiometry | DXA; Lunar DPX IQ-USA | 21 | 80 | 0.63 ± 0.17 | 0.68 ± 0.17 | – | – |