Application of the adenosine triphosphate sensitivity assay in infantile vascular anomalies

Li, Li; Yang, Bin; Wei, Li; Zhang, Bin; Han, Xiao-feng; Xu, Zi-gang; Ma, Lin

doi:10.1186/s12887-020-1974-9

BMC Pediatrics

Table 2 Testing result of 11 cases capillary malformations specimens, growth inhibition rates (%)

From: Application of the adenosine triphosphate sensitivity assay in infantile vascular anomalies

Testing drug	400%	200%	100%	50%	25%	12.5%	TGI
Patient No.1
Propranolol	−6.98	−19.18	−14.02	−15.42	−7.98	−13.91	−77.49
Rapamycin	10.71	−15.56	−8.48	19.28	12.73	10.09	28.77
Sildenafil	−18.21	−3.58	2.79	−19.52	−12.89	− 8.21	−59.62
Itraconazole	61.01	35.15	10.15	−2.34	−11.28	−3.06	89.63
Patient No.2
Propranolol	−23.96	7.19	−6.83	−25.35	3.14	−16.09	− 61.90
Rapamycin	30.14	29.28	7.05	13.38	24.11	−6.67	97.29
Sildenafil	−24.71	−10.00	− 25.87	−4.61	−12.19	− 47.52	− 124.9
Itraconazole	58.00	20.68	6.96	−17.90	− 18.74	−9.75	39.25
Patient No.3
Propranolol	−43.29	−19.52	−15.63	−3.46	−8.10	− 19.72	− 109.72
Rapamycin	28.18	48.20	49.61	59.12	45.48	42.99	273.58
Sildenafil	−3.51	8.34	−7.31	−8.34	−10.17	−14.19	− 35.18
Itraconazole	27.82	29.63	−3.77	−8.82	−9.20	−8.41	27.25
Patient No.4
Propranolol	−14.52	−6.70	11.50	9.24	−15.89	−8.00	−24.37
Rapamycin	61.07	61.52	59.12	62.74	58.41	60.01	362.87
Sildenafil	−13.62	−12.51	−15.82	− 19.69	−20.55	−22.43	− 104.62
Itraconazole	48.74	17.26	−3.79	−13.68	−9.71	−6.65	32.17
Patient No.5
Propranolol	−25.19	− 24.47	− 15.96	−5.67	−9.79	−14.35	− 95.43
Rapamycin	33.80	37.30	36.81	36.86	37.58	37.39	219.74
Sildenafil	−9.62	5.53	9.88	5.10	5.56	9.34	25.79
Itraconazole	55.08	52.15	34.02	12.58	22.94	14.98	191.75
Patient No.6
Propranolol	25.94	6.19	−10.22	−26.36	−18.57	−50.00	−73.02
Rapamycin	13.42	−11.34	−41.93	0.35	−19.40	−16.90	−75.8
Sildenafil	−1.60	17.59	−5.49	−3.55	38.46	3.42	48.83
Itraconazole	91.59	57.65	46.24	−2.16	7.02	−0.21	200.13
Patient No.7
Propranolol	19.12	10.04	13.45	−12.48	6.71	9.44	46.28
Rapamycin	28.33	28.26	27.07	19.75	17.94	16.43	137.78
Sildenafil	12.78	17.26	−11.37	3.84	−0.74	−21.08	0.69
Itraconazole	57.51	42.83	16.52	21.09	13.09	12.72	163.76
Patient No.8
Propranolol	−3.20	−1.04	−10.86	−17.05	− 14.17	0.83	−45.49
Rapamycin	2.01	5.93	−1.23	−6.97	−17.91	−5.67	−23.84
Sildenafil	4.26	−6.58	−10.47	−17.54	−25.50	−6.80	−62.63
Patient No.9
Propranolol	−27.68	−29.55	−42.66	−33.58	− 29.81	−73.67	− 236.95
Rapamycin	28.00	26.94	28.25	20.65	31.59	−3.94	131.49
Sildenafil	−58.38	−57.51	−47.19	− 49.11	−46.99	− 118.09	− 377.27
Patient No.10
Propranolol	7.06	−3.30	−10.75	−16.81	− 10.72	15.52	− 19
Rapamycin	47.64	51.80	51.03	47.49	39.85	44.70	282.51
Sildenafil	17.91	2.59	5.02	−1.91	−0.90	16.28	38.99
Patient No.11
Propranolol	−1.52	− 18.04	−86.25	−23.50	−24.81	−56.10	− 210.22
Rapamycin	74.36	79.44	75.57	75.02	70.64	73.95	448.98
Sildenafil	−39.53	1.07	−7.27	−4.22	20.95	− 38.48	−67.48

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