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Table 4 Factors of gastrointestinal perforation stratified by fluoroquinolones subgroup in different tracking period by using Cox regression

From: The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan

Tracking periodFluoroquinolones subgroupPopulationsEventsPDsRate (per 105 PDs)Adjusted HR95% CI95% CIPAdjusted HR95% CI95% CIP
3-dayWithout133,684223,707,602.750.01Reference   Reference   
With33,42105,940,776.060.000.0000.995    
 Levofloxacin6530112,735.690.00    0.0000.960
 Ciprofloxaxin18430316,411.560.00    0.0000.978
 Moxifloxacin139024,500.000.00    0.0000.988
 Gemifloxacin1202160.000.00    0.0000.998
 Norfloxacin704101,261,596.870.00    0.0000.996
 Ofloxacin23,73304,223,371.940.00    0.0000.990
7-dayWithout133,684623,707,602.750.03Reference   Reference   
With33,42115,940,776.060.020.5120.08027.4260.756    
 Levofloxacin6530112,735.690.00    0.0000.982
 Ciprofloxaxin18430316,411.560.00    0.0000.979
 Moxifloxacin139024,500.000.00    0.0000.993
 Gemifloxacin1202160.000.00    0.0000.986
 Norfloxacin704101,261,596.870.00    0.0000.978
 Ofloxacin23,73314,223,371.940.02    0.7760.11472.3010.442
14-dayWithout133,6841023,707,602.750.04Reference   Reference   
With33,42135,940,776.060.051.0250.0441.3560.111    
 Levofloxacin6530112,735.690.00    0.0000.986
 Ciprofloxaxin18431316,411.560.32    1.5720.0527.1660.678
 Moxifloxacin139024,500.000.00    0.0000.995
 Gemifloxacin1202160.000.00    0.0000.986
 Norfloxacin704111,261,596.870.08    1.3420.0206.9880.501
 Ofloxacin23,73314,223,371.940.02    0.4270.0354.9720.494
28-dayWithout133,6841423,707,602.750.06Reference   Reference   
With33,42145,940,776.060.071.1370.0901.4980.157    
 Levofloxacin6530112,735.690.00    0.0000.978
 Ciprofloxaxin18431316,411.560.32    1.2660.0282.9990.267
 Moxifloxacin139024,500.000.00    0.0000.978
 Gemifloxacin1202160.000.00    0.0000.964
 Norfloxacin704111,261,596.870.08    2.0520.18422.4850.532
 Ofloxacin23,73324,223,371.940.05    0.3070.5551.7520.188
3-monthWithout133,6844523,707,602.750.19Reference   Reference   
With33,421125,940,776.060.201.0490.1561.9250.198    
 Levofloxacin6530112,735.690.00    0.0000.952
 Ciprofloxaxin18431316,411.560.32    1.0760.0131.9720.129
 Moxifloxacin139024,500.000.00    0.0000.978
 Gemifloxacin1202160.000.00    0.0000.986
 Norfloxacin704131,261,596.870.24    1.4720.4025.4110.524
 Ofloxacin23,73384,223,371.940.19    0.3900.1451.7860.379
6-monthWithout133,6846823,707,602.750.29Reference   Reference   
With33,421175,940,776.060.291.3300.7782.2760.255    
 Levofloxacin6530112,735.690.00    0.0000.975
 Ciprofloxaxin18431316,411.560.32    1.4020.19710.1210.702
 Moxifloxacin139024,500.000.00    0.0000.966
 Gemifloxacin1202160.000.00    0.0000.973
 Norfloxacin704131,261,596.870.24    0.9110.3483.5260.813
 Ofloxacin23,733134,223,371.940.31    1.4420.7932.6010.199
  1. PDs Person-days, Adjusted HR Adjusted hazard ratio: Adjusted for the variables listed in Table 2, CI Confidence interval