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Table 2 Factors of gastrointestinal perforation in 6-month tracking by using Cox regression

From: The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan

VariablesCrude HR95% CI95% CIPAdjusted HR95% CI95% CIPAdjusted HR95% CI95% CIP
Fluoroquinolones
 WithoutReference   Reference   Reference   
 With0.9970.5861.6960.9901.3290.7762.2740.2571.3300.7782.2760.255
Gender
 Male1.1530.7531.7640.5131.0400.7911.3400.0621.0330.8091.3820.064
 FemaleReference   Reference   Reference   
Age (years)0.9760.9391.0140.2140.9680.9311.0060.094    
Age group (years)
 < 1Reference       Reference   
 11.8350.7084.7560.212    2.0470.7845.3450.123
 20.6200.1062.2900.473    0.6690.8102.4880.556
 31.8020.7154.5400.212    1.8220.7524.6480.189
 40.3680.0791.7030.201    0.3810.8801.7780.225
 5–90.4410.1931.0080.052    0.4330.1790.9520.040
 10–140.4150.1770.9710.043    0.3860.1630.9090.028
150.9440.4422.0140.881    0.8310.3841.7890.661
Catastrophic illness
 WithoutReference   Reference   Reference   
 With5.9720.014161.7820.9852.7400.29213.4210.9282.7390.29113.4110.938
Low-income household
 WithoutReference   Reference   Reference   
 With1.6430.0904.6200.6611.5460.0764.1050.5781.5410.0724.0700.572
Season
 SpringReference   Reference   Reference   
 Summer0.2180.1270.377< 0.0010.2090.1210.362< 0.0010.0220.1260.374< 0.001
 Autumn0.0170.0060.047< 0.0010.0180.0060.048< 0.0010.0170.0070.050< 0.001
 Winter0.0560.0320.098< 0.0010.0570.0320.099< 0.0010.0570.0320.100< 0.001
Urbanization level
 1 (the highest)1.9931.0323.8490.0402.0341.0334.0020.0332.0431.0314.0240.029
 20.5960.2761.2880.1880.5260.2391.1440.1150.5270.2421.1460.116
 32.3571.1844.6910.0152.5811.2945.1460.0032.5861.2945.1530.006
 4 (the lowest)Reference   Reference   Reference   
Level of care
 Hospital center2.9091.2326.8710.0152.7681.1326.7590.0142.7571.1246.7340.010
 Regional hospital7.6134.60812.579< 0.0018.3515.00813.884< 0.0018.4805.02914.208< 0.001
 Local hospital6.2133.42511.269< 0.0015.3042.9119.672< 0.0015.2222.8649.526< 0.001
 Physician clinicsReference   Reference   Reference   
Comorbidities (No reference)
 Cerebrovascular accident10.4540.02225.1240.9865.1310.00916.7520.9925.1040.00916.6410.992
 Diabetes mellitus3.4010.5646.7850.2983.1050.4826.1310.3843.0780.4766.0790.390
 Hypertension1.8980.6753.9960.7441.7760.6033.2970.7561.6230.5983.1110.758
 Hyperlipidemia0.0000.9890.0000.9970.0000.997
Drugs (No reference)
 NSAID1.2640.8421.6770.5621.1890.6751.5970.5991.1870.6731.5890.598
 Systemic steroid1.1010.7651.2970.4381.0860.5671.2730.5011.0850.5611.2700.497
  1. HR Hazard ratio, CI Confidence interval, Adjusted HR Adjusted variables listed in the table, NSAID Non-steroidal anti-inflammatory drugs