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Table 1 Characteristics of study

From: The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan

FluoroquinolonesTotalWithWithoutP
Variablesn%n%n%
Total167,105 33,42120.00133,68480.00 
Collagen-associated adverse events      0.990
 Without167,02099.9533,40499.95133,61699.95 
 With850.05170.05680.05 
Collagen-associated adverse events subgroups      0.990
 Without167,02099.9533,40499.95133,61699.95 
 Tendons rupture00.0000.0000.00 
 Retinal detachments00.0000.0000.00 
 Gastrointestinal perforation850.05170.05680.05 
 Aortic dissection/Aortic aneurysm00.0000.0000.00 
Gender      0.999
 Male85,99051.4617,19851.4668,79251.46 
 Female81,11548.5416,22348.5464,89248.54 
Age (years)9.78 ± 5.589.83 ± 5.359.77 ± 5.630.079
Age group (years)      0.999
 < 151003.0510203.0540803.05 
 171454.2814294.2857164.28 
 279704.7715944.7763764.77 
 390605.4218125.4272485.42 
 410,6806.3921366.3985446.39 
 5–946,67027.93933427.9337,33627.93 
 10–1442,78525.60855725.6034,22825.60 
1537,69522.56753922.5630,15622.56 
Catastrophic illness      < 0.001
 Without166,39899.5833,22299.40133,17699.62 
 With7070.421990.605080.38 
Low-income household      < 0.001
 Without164,08998.2032,56197.43131,52898.39 
 With30161.808602.5721561.61 
Season      < 0.001
 Spring (Mar - May)43,86726.25875726.2035,11026.26 
 Summer (Jun - Aug)42,83625.63843525.2434,40125.73 
 Autumn (Sep - Nov)41,28724.71828924.8032,99824.68 
 Winter (Dec - Feb)39,11523.41794023.7631,17523.32 
Urbanization level      < 0.001
 1 (the highest)45,24027.07734321.9737,89728.35 
 262,22237.2411,92935.6950,29337.62 
 327,98016.74643319.2521,54716.12 
 4 (the lowest)31,66318.95771623.0923,94717.91 
Level of care      < 0.001
 Hospital center75594.5212683.7962914.71 
 Regional hospital11,8587.1019395.8099197.42 
 Local hospital87625.4915884.9471745.63 
 Physician clinics138,92683.1428,62685.65110,30082.51 
Comorbidities
 Cerebrovascular accident430.0380.02350.030.819
 Diabetes mellitus840.05180.05660.050.743
 Hypertension960.06200.06760.060.838
 Hyperlipidemia740.04150.04590.040.954
Drugs
 Non-steroidal anti-inflammatory drugs50083.0010233.0639852.980.443
 Systemic steroid9150.551880.567270.540.679
  1. P: Chi-square / Fisher exact test on category variables and t-test on continue variables