Table 1 Maternal baseline characteristics, pregnancy outcome and neonatal data
From: Cognitive function in metformin exposed children, born to mothers with PCOS – follow-up of an RCT
Metformin (n = 52) | Placebo (n = 41) | p-value | |
|---|---|---|---|
Baseline data of the mothers in 1st trimester | Mean (SD) | Mean (SD) | |
Age (years) | 29.3 (3.4) | 29.0 (4.3) | .762 |
Weight (kg) | 84.7 (19.4) | 79.5 (19.2) | .215 |
BMIa (kg/m2) | 30.2 (7.0) | 27.9 (6.3) | .105 |
BPb systolic | 121 (14) | 117 (10) | .157 |
BP diastolic | 75 (10) | 74 (7) | .569 |
Phenotype PCOSc: | n (%) | n (%) | .397 |
A | 26 (59) | 21 (62) | |
B | 1 (2) | 0 | |
C | 5 (11) | 1 (3) | |
D | 12 (27) | 12 (35) | |
Smoking | 4 (8) | 1 (3) | .279 |
Pregnancy outcome | |||
Gestational diabetes | 12 (24) | 11 (28) | .614 |
Preeclampsia | 4 (8) | 2 (5) | .609 |
Pre-term delivery | 1 (2) | 4 (10) | .089 |
Mean (SD) | Mean (SD) | ||
Breastfeeding (months) | 8.5 (4.5) | 8.3 (3.8) | .864 |
Adherence to study medicationd | n (%) | n (%) | .724 |
Good | 42 (82) | 30 (77) | |
Acceptable | 3 (6) | 4 (10) | |
Poor | 6 (12) | 5 (13) | |
Neonatal data | |||
Gender male/female | 22/28 | 17/23 | .887 |
Apgar< 7 at 5 min | 0 | 1 (3) | .252 |
Mean (SD) | Mean (SD) | ||
Weight (g) | 3475 (482) | 3582 (793) | .491 |
Weight z-score | −0.28 (1.1) | 0.07 (0.9) | .133 |
Length (cm) | 49.8 (2.1) | 49.7 (3.4) | .933 |
Length z-score | −0.71 (1.3) | − 0.49 (1.2) | .425 |
Head circumference (cm) | 35.7 (1.2) | 34.7 (1.8) | .009 |
Head circumference z-score | 0.50 (1.0) | −0.02 (1.0) | .022 |
Gestational age (weeks) | 39.1 (1.3) | 38.7 (2.7) | .508 |