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Table 3 Comparison of antibiotic and acyclovir usage between the control and mPCR group

From: Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study

 Control groupmPCR groupp valuea
I. Antibiotic therapy
 Patients with suspicion of Meningitis/ Meningoencephalitis42/46 (91.3%)42/46 (91.3%) 
  Infants28/29 (96.6%)28/29 (96.6%) 
   ≥ 1 year14/17 (82.4%)14/17 (82.4%) 
 LoT (antibiotics)4.0 (3.0–5.0)3.0 (1.0–5.0)0.028
  Infants4.0 (3.5–5.5)3.0 (2.0–5.0)0.038
   ≥ 1 year4.0 (3.0–5.0)2.5 (1.0–7.0)0.280
 DoT (antibiotics)6.0 (4.0–10.0)4.0 (2.0–8.0)0.023
  Infants8.0 (6.0–11.0)6.0 (3.5–10.0)0.015
   ≥ 1 year4.0 (3.0–5.0)2.5 (1.0–7.0)0.280
II. Acyclovir therapy
 Patients with suspicion of Meningoencephalitis/ Encephalitis33/46 (71.7%)33/46 (71.7%) 
  Infants19/29 (65.5%)19/29 (65.5%) 
   ≥ 1 year14/17 (82.4%)14/17 (82.4%) 
 LoT (acyclovir)3.0 (3.0–4.0)1.0 (1.0–2.0)< 0.001
  Infants3.0 (3.0–4.0)1.0 (1.0–2.0)< 0.001
   ≥ 1 year3.0 (3.0–4.0)1.0 (1.0–2.0)< 0.001
  1. The exact Mann-Whitney-U-Test was used to compare distributions of quantitative variables between independent groups. Quantitative data are described by median (M) and interquartile range (IQR). Categorical data are presented as absolute number/ total (percentage) [n/N (%)]
  2. Abbreviations: multiplex PCR (mPCR), Length of Therapy (LoT), Days of Therapy (DoT)
  3. aThe p value always refers to the comparison of the number of patients being prescribed either antibiotics or acyclovir in the control and mPCR group