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Table 2 PCR testing for viral pathogens in CSF in both study groups

From: Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study

 

Control group

mPCR group

p value

Viral pathogens included in the FA ME Panel

 Cytomegalovirus

3/46 (6.5%)

46/46 (100.0%)

< 0.001

  Infants

1/29 (3.4%)

29/29 (100.0%)

< 0.001

   ≥ 1 year

2/17 (11.8%)

17/17 (100.0%)

< 0.001

 Enterovirus

18/46 (39.1%)

46/46 (100.0%)

< 0.001

  Infants

8/29 (27.6%)

29/29 (100.0%)

< 0.001

   ≥ 1 year

10/17 (58.8%)

17/17 (100.0%)

0.007

 Herpes simplex virus 1/2

43/46 (93.5%)

46/46 (100.0%)

0.242

  Infants

26/29 (89.7%)

29/29 (100.0%)

0.237

   ≥ 1 year

17/17 (100.0%)

17/17 (100.0%)

–

 Human herpesvirus 6

2/46 (4.3%)

46/46 (100.0%)

< 0.001

  Infants

0/29 (0.0%)

29/29 (100.0%)

< 0.001

   ≥ 1 year

2/17 (11.8%)

17/17 (100.0%)

< 0.001

 Human parechovirus

0/46 (0.0%)

46/46 (100.0%)

< 0.001

  Infants

0/29 (0.0%)

29/29 (100.0%)

< 0.001

   ≥ 1 year

0/17 (0.0%)

17/17 (100.0%)

< 0.001

 Varicella zoster virus

3/46 (6.5%)

46/46 (100.0%)

< 0.001

  Infants

0/29 (0.0%)

29/29 (100.0%)

< 0.001

   ≥ 1 year

3/17 (17.6%)

17/17 (100.0%)

< 0.001

Other viral pathogens

 Human herpesvirus 7

3/46 (6.5%)

0/46 (0 .0%)

0.242

  Infants

0/29 (0.0%)

0/29 (0.0%)

–

   ≥ 1 year

3/17 (17.6%)

0/17 (0.0%)

0.227

 Epstein-Barr virus

3/46 (6.5%)

0/46 (0.0%)

0.242

  Infants

3/29 (10.3%)

0/29 (0.0%)

0.237

   ≥ 1 year

0/17 (0.0%)

0/17 (0.0%)

–

 Adenovirus

3/46 (6.5%)

1/46 (2.2%)

0.617

  Infants

1/29 (3.4%)

1/29 (3.4%)

1.000

   ≥ 1 year

2/17 (11.8%)

0/17 (0.0%)

0.485

 Influenza A virus

1/46 (2.2%)

0/46 (0.0%)

1.000

  Infants

0/29 (0.0%)

0/29 (0.0%)

–

   ≥ 1 year

1/17 (5.9%)

0/17 (0.0%)

1.000

 Influenza B virus

1/46 (2.2%)

0/46 (0.0%)

1.000

  Infants

0/29 (0.0%)

0/29 (0.0%)

–

   ≥ 1 year

1/17 (5.9%)

0/17 (0.0%)

1.000

 Measles virus

1/46 (2.2%)

0/46 (0.0%)

1.000

  Infants

0/29 (0.0%)

0/29 (0.0%)

–

   ≥ 1 year

1/17 (5.9%)

0/17 (0.0%)

1.000

 Mumps virus

1/46 (2.2%)

0/46 (0.0%)

1.000

  Infants

0/29 (0.0%)

0/29 (0.0%)

–

   ≥ 1 year

1/17 (5.9%)

0/17 (0.0%)

1.000

  1. The Fisher’s exact test was used for categorical variables. Categorical data are presented as absolute number/ total (percentage) [n/N (%)]
  2. Abbreviations: cerebrospinal fluid (CSF), multiplex PCR (mPCR), FilmArray Meningitis/Encephalitis Panel (FA ME Panel)