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Table 2 PCR testing for viral pathogens in CSF in both study groups

From: Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study

 Control groupmPCR groupp value
Viral pathogens included in the FA ME Panel
 Cytomegalovirus3/46 (6.5%)46/46 (100.0%)< 0.001
  Infants1/29 (3.4%)29/29 (100.0%)< 0.001
   ≥ 1 year2/17 (11.8%)17/17 (100.0%)< 0.001
 Enterovirus18/46 (39.1%)46/46 (100.0%)< 0.001
  Infants8/29 (27.6%)29/29 (100.0%)< 0.001
   ≥ 1 year10/17 (58.8%)17/17 (100.0%)0.007
 Herpes simplex virus 1/243/46 (93.5%)46/46 (100.0%)0.242
  Infants26/29 (89.7%)29/29 (100.0%)0.237
   ≥ 1 year17/17 (100.0%)17/17 (100.0%)–
 Human herpesvirus 62/46 (4.3%)46/46 (100.0%)< 0.001
  Infants0/29 (0.0%)29/29 (100.0%)< 0.001
   ≥ 1 year2/17 (11.8%)17/17 (100.0%)< 0.001
 Human parechovirus0/46 (0.0%)46/46 (100.0%)< 0.001
  Infants0/29 (0.0%)29/29 (100.0%)< 0.001
   ≥ 1 year0/17 (0.0%)17/17 (100.0%)< 0.001
 Varicella zoster virus3/46 (6.5%)46/46 (100.0%)< 0.001
  Infants0/29 (0.0%)29/29 (100.0%)< 0.001
   ≥ 1 year3/17 (17.6%)17/17 (100.0%)< 0.001
Other viral pathogens
 Human herpesvirus 73/46 (6.5%)0/46 (0 .0%)0.242
  Infants0/29 (0.0%)0/29 (0.0%)–
   ≥ 1 year3/17 (17.6%)0/17 (0.0%)0.227
 Epstein-Barr virus3/46 (6.5%)0/46 (0.0%)0.242
  Infants3/29 (10.3%)0/29 (0.0%)0.237
   ≥ 1 year0/17 (0.0%)0/17 (0.0%)–
 Adenovirus3/46 (6.5%)1/46 (2.2%)0.617
  Infants1/29 (3.4%)1/29 (3.4%)1.000
   ≥ 1 year2/17 (11.8%)0/17 (0.0%)0.485
 Influenza A virus1/46 (2.2%)0/46 (0.0%)1.000
  Infants0/29 (0.0%)0/29 (0.0%)–
   ≥ 1 year1/17 (5.9%)0/17 (0.0%)1.000
 Influenza B virus1/46 (2.2%)0/46 (0.0%)1.000
  Infants0/29 (0.0%)0/29 (0.0%)–
   ≥ 1 year1/17 (5.9%)0/17 (0.0%)1.000
 Measles virus1/46 (2.2%)0/46 (0.0%)1.000
  Infants0/29 (0.0%)0/29 (0.0%)–
   ≥ 1 year1/17 (5.9%)0/17 (0.0%)1.000
 Mumps virus1/46 (2.2%)0/46 (0.0%)1.000
  Infants0/29 (0.0%)0/29 (0.0%)–
   ≥ 1 year1/17 (5.9%)0/17 (0.0%)1.000
  1. The Fisher’s exact test was used for categorical variables. Categorical data are presented as absolute number/ total (percentage) [n/N (%)]
  2. Abbreviations: cerebrospinal fluid (CSF), multiplex PCR (mPCR), FilmArray Meningitis/Encephalitis Panel (FA ME Panel)
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BMC Pediatrics

ISSN: 1471-2431

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