Cost effectiveness of a novel device for improving resuscitation of apneic newborns

BMC Pediatrics

Table 2 Results of the Base Case and Sensitivity Analyses

Parameter Description (Base Case Value)	Direction	Value	Cost per DALY Averted (Min, Max)
Base Case (N/A)	N/A	N/A	24.44 (4.80, 73.62)
Proportion of Time of Leaking with AIR** (0.700)	Upper Estimate	0.85	51.27 (10.68, 510.02)
Proportion of Time of Leaking with AIR** (0.700)	Lower Estimate	0.05	7.75 (1.80, 16.59)
Hazard Ratio Mortality of Moderate to Severe Impairment (11.36)	Upper Estimate	20.00	23.39 (5.20, 61.75)
	Lower Estimate	2.50	26.43 (5.31, 109.50)
Hazard Ratio Mortality of Mild Impairment (3.15)	Upper Estimate	10.00	25.21 (4.66, 85.00)
Hazard Ratio Mortality of Mild Impairment (3.15)	Lower Estimate	1.50	27.10 (4.59, 174.21)
Facility Births per Year	Upper Estimate	9000	11.76 (2.72, 36.81)
Facility Births per Year	Lower Estimate	2250	48.26 (10.83, 170.01)
Cost of AIR Device	Upper Estimate	250	44.63 (9.26, 129.06)
Cost of AIR Device	Lower Estimate	100	20.43 (4.78, 72.92)
Probability of Apnea at Birth (0.0547)	Upper Estimate	0.109	11.68 (2.48, 28.51)
Probability of Apnea at Birth (0.0547)	Lower Estimate	0.027	52.48 (8.00, 259.71)

Key: DALY (Disability-Adjusted Life Year), AIR (Augmented Infant Resuscitator)
*Costs are presented as a mean value and a lower (minimum) and upper (maximum) bound that reflect the range of uncertainty in the calibrated parameter sets
**Defined as (t _AIR / t _{NO AIR}), where t is the time spent leaking. Ratios closer to 0 are favorable for the AIR, as less time is spent leaking. Ratios closer to 1 reflect decreased effectiveness of the AIR, as the time spent leaking with the device is comparable to the time leaking without its use

ISSN: 1471-2431