Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma

BMC Pediatrics

Table 1 Demographics and initial treatment in 116 patients at diagnosis of retinoblastoma

	All patients	Unilateral	Bilateral	Trilateral	p-value ^a)
Number of patients	116	77	38	1
eyes	155	77	76	2
Male / female	58 / 58	36 / 41	21 / 17	1 / 0	0.432
Positive family history ^b)	10	2	8	0	0.002
Age at diagnosis ^c), month	13 (0–101)	20 (0–101)	5 (0–28)	18	3.17 × 10-
Observation period ^b), month	133 (10–403)	113 (10–403)	188 (15–370)	18	0.026
Initial treatment
Enucleation alone	69	69	0	0
Local therapy alone	6	0	6	0
External beam radiotherapy	19	2	17	0
Systemic chemotherapy	22	6	15	1

^a) Statistical comparisons between patients with unilateral tumors and those with bilateral tumors were
performed, using chi-square test, Fisher’s exact test and Mann-Whitney U test
^b) The germline mutation of RB1 was studied in only a few patients
^c) Each value represents the median age or observation period (months), with the range in parenthesis

ISSN: 1471-2431