Fig. 1

Investigations recommended on received guidelines to determine the aetiology of neonatal seizures: Red – 1st line; blue – 2nd line or only to be requested under certain circumstances; orange – 3rd line. Guideline from centre G did not attempt to recommend investigations. Abbreviations: FBC – full blood count; U&E – urea and electrolytes; LFT – liver function tests; CK – creatine kinase, TFT – thyroid function test; AA – amino acids; VLCFA – very long chain fatty acids; CRP – C-reactive protein; OA – organic acids; AASA – alpha amino adipic semialdehyde; MRI – magnetic resonance imaging; aEEG – amplitude integrated electroencephalography; EEG – electroencephalography