Fig. 1
From: Multisystem mitochondrial diseases due to mutations in mtDNA-encoded subunits of complex I
MRI of the brain in P1–P3 and P5–P12 with complex I deficiency. Signal changes in basal ganglia or brainstem characteristic for Leigh syndrome are present in patients P2, P6, P9, P10 and P13. Signal changes in the cortex and white matter of the hemispheres or cerebellum with stroke-like lesion are present in patients P5, P8, P11, and the combination of both changes are visible in patients P1, P3, P7 and P12. Moderate to severe periventricular atrophy was found in patients P1, P3 and P5.