Fig. 3From: Infantile onset Sandhoff disease: clinical manifestation and a novel common mutation in Thai patientsStructural homology of the Cys551Tyr and Leu254Ser. a Molecular model of Cys551Tyr. Noted loss of the disulfide bond between Cys534 and Cys551 and additional hydrogen bond formation between Cys534 and Thr530. b Homological model of Leu254Ser, indicating one additional hydrogen bond forming between Ser254 and Phe251Back to article page