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Sepsis
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Positive blood culture with an organism not typically considered a contaminant
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Urinary tract infection
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Positive urine culture with an organism not typically considered a contaminant
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Bacterial meningitis
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Positive cerebrospinal fluid culture with an organism not typically considered a contaminant
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Retinopathy of Prematurity (ROP)
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ROP requiring treatment with laser photocoagulation or an anti-VEGF drug
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Seizures
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Determined by the treating provider
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Abnormal hearing test results
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Based on testing during primary hospitalization
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Systemic arterial or deep venous thrombosis
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Thrombosis requiring treatment with anticoagulation (e.g., heparin or low-molecular-weight heparin)
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Direct hyperbilirubinemia
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Conjugated serum bilirubin > 2.0 mg/dL
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Elevated transaminases
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ALT > 150 U/L or AST > 225 U/L
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Endotracheal intubation
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Intubation and transition from non-invasive to invasive ventilation, not due to planned surgical procedure (e.g., inguinal hernia repair or ROP treatment)
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