Skip to main content

Table 3 Variables associated by low body perfusion and hypoxia for infants before NEC development

From: Hypoxic/ischemic hits predispose to necrotizing enterocolitis in (near) term infants with congenital heart disease: a case control study

  NEC n Control n P
Apgar score at 1 minute a 8 (7–8) 12 9 (8–9) 12 0.01
Apgar score at 5 minutes a 8 (8–9) 12 9 (9–10) 12 0.009
Respiratory support in the delivery room (%) a 11 (69) 16 2 (13) 16 0.001
Diastolic blood pressure 0–24 h (mm Hg) a 42 (34–44) 16 40 (38–48) 16 0.49
Diastolic blood pressure 24–48 h (mm Hg)b 39 (34–42) 10 43 (37–51) 10 0.11
Systolic blood pressure 0–24 h (mm Hg) a 68 (63–76) 16 72 (66–77) 16 0.37
Systolic blood pressure 24–48 h (mm Hg)b 67 (62–74) 10 70 (68–80) 10 0.29
First Hb measurement (mmol/L)b 9.3 (8.7–10.1) 11 10.8 (9.1–11.6) 11 0.26
Lowest pH measurement a 7.24 (7.17–7.35) 9 7.38 (7.27–7.43) 9 0.16
Metabolic acidosis 4 (44) 9 2 (22) 9 0.62
Post-ductal SpO2 0–24 h a 91 (89–96) 13 93 (89–94) 13 0.58
Post-ductal SpO2 24–48 h b 93 (89–95) 12 93 (90–95) 12 0.88
Heart rate 0–24 h a 143 (142–157) 11 146 (134–154) 11 0.49
Heart rate 24–48 hb 149 (138–155) 8 140 (133–150) 8 0.40
Respiratory support 0–24 h (%) a 9 (56) 16 10 (63) 16 0.70
Respiratory support 24–48 h (%)b 4 (50) 8 4 (50) 8 1.00
Prostaglandin E1 0–24 h (%) a 8 (50) 16 11 (69) 16 0.28
Prostaglandin E1 24–48 h (%)b 4 (44) 9 5 (56) 9 1.00
Inotropes (%) a 2 (13) 16 1 (6) 16 1.00
Internal ductal diameter (mm) a 2.8 (1.9–3.4) 11 3.3 (3.0-3.6) 11 0.17
LA:Ao-ratio a 1.7 (1.5–2.3) 9 1.8 (1.4–1.9) 9 0.51
LVEDD (mm) a 16.0 (11.2–20.0) 10 15.5 (14.2–18.1) 10 0.94
Diastolic backflow in the descending aorta (%) a 6 (55) 11 5 (46) 11 0.67
Diastolic forward blood flow in the pulmonary arteries (%) a 7 (70) 10 7 (70) 10 1.00
  1. Data are shown as either n (%) for categorical variables and mean ± standard deviation or median (IQR) for continuous variables. a: Maximum of 16 infants used for the variable. b: Maximum of 13 infants used for the variable due to the development of NEC in 3 infants. LA:Ao-ratio: left atrium-aortic root ratio. LVEDD: Left ventricular end diastolic diameter