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Table 2 Vital signs over time (6-hour intervals) post benzodiazepine treatment (n = 30)

From: Oral clonazepam versus lorazepam in the treatment of methamphetamine-poisoned children: a pilot clinical trial

Variable BZO Time post initiation of oral benzodiazepine (hours) p-value* Pairwise comparison
   T0 T6 T12 T18 T24   
Heart ratea Lorazepam 130 [110, 150]
(90, 160)
112 [110, 128]
(100, 140)
110 [102, 112]
(90, 120)
102 [100, 112]
(88, 130)
100 [99, 110]
(80, 126)
< 0.001 T0 vs. T24
T6 vs. T24
T0 vs. T18
Clonazepam 120 [100, 140]
(92, 144)
115[106, 122]
(100, 148)
107 [100, 110]
(80, 127)
110 [97, 119]
(88, 123)
108 [98, 120]
(88, 120)
0.673  
Temperaturea Lorazepam 37 [36.6, 37]
(36, 37.1)
37 [36.9, 37]
(36.7, 37.8)
36.8 [36.5, 37]
(36.2, 37.5)
36.8 [36.5, 37]
(36.2, 37.5)
36.5 [36.5, 36.8]
(36.2, 37)
0.002 T6 vs. T24
Clonazepam 37 [36.6, 37]
(36, 37.2)
37 [36.9, 37]
(36.5, 37)
36.8 [36.5, 37]
(36, 37.2)
37 [36.5, 37]
(36.5, 37.2)
36.5 [36.5, 36.9]
(36.5, 37)
0.242 -
Respiratory ratea Lorazepam 30 [26, 35]
(20, 60)
25 [22, 27]
(20 ,55)
25 [22, 25]
(18 ,50)
23 [22, 26]
(20 ,26)
22 [22, 24]
(21 ,25)
0.006 T0 vs. T12
T6 vs. T24
Clonazepam 30 [24, 33]
(16, 60)
29 [20, 32]
(20 ,40)
25 [21, 29]
(18 ,35)
25 [21, 29]
(18 ,30)
24 [19, 25]
(18 ,30)
0.003 T0 vs. T24
T6 vs. T24
Systolic blood pressurea Lorazepam 92 [90, 100]
(80, 100)
92 [90, 90]
(80, 100)
90 [80, 97]
(80, 100)
90 [75, 100]
(70, 100)
90 [77, 92]
(70, 100)
0.647 -
Clonazepam 90 [90, 100]
(80, 110)
90 [90, 100]
(80, 110)
85 [80, 90]
(80, 100)
85 [80, 85]
(70, 90)
75 [70, 75]
(70, 100)
0.160 -
  1. *Using Friedman’s two-way ANOVA
  2. aMedian [IQR] (min, max)