Table 2 Vital signs over time (6-hour intervals) post benzodiazepine treatment (n = 30)
| Variable | BZO | Time post initiation of oral benzodiazepine (hours) | p-value* | Pairwise comparison | ||||
|---|---|---|---|---|---|---|---|---|
| T0 | T6 | T12 | T18 | T24 | ||||
| Heart ratea | Lorazepam |
130 [110, 150]
(90, 160) |
112 [110, 128]
(100, 140) |
110 [102, 112] (90, 120) |
102 [100, 112]
(88, 130) |
100 [99, 110]
(80, 126) | < 0.001 |
T0 vs. T24 T6 vs. T24 T0 vs. T18 |
| Clonazepam |
120 [100, 140] (92, 144) |
115[106, 122] (100, 148) |
107 [100, 110] (80, 127) |
110 [97, 119] (88, 123) |
108 [98, 120] (88, 120) | 0.673 | ||
| Temperaturea | Lorazepam |
37 [36.6, 37] (36, 37.1) |
37 [36.9, 37]
(36.7, 37.8) |
36.8 [36.5, 37] (36.2, 37.5) |
36.8 [36.5, 37] (36.2, 37.5) |
36.5 [36.5, 36.8]
(36.2, 37) | 0.002 | T6 vs. T24 |
| Clonazepam |
37 [36.6, 37] (36, 37.2) |
37 [36.9, 37] (36.5, 37) |
36.8 [36.5, 37] (36, 37.2) |
37 [36.5, 37] (36.5, 37.2) |
36.5 [36.5, 36.9] (36.5, 37) | 0.242 | - | |
| Respiratory ratea | Lorazepam |
30 [26, 35]
(20, 60) |
25 [22, 27] (20 ,55) |
25 [22, 25]
(18 ,50) |
23 [22, 26] (20 ,26) |
22 [22, 24]
(21 ,25) | 0.006 |
T0 vs. T12 T6 vs. T24 |
| Clonazepam |
30 [24, 33]
(16, 60) |
29 [20, 32]
(20 ,40) |
25 [21, 29] (18 ,35) |
25 [21, 29] (18 ,30) |
24 [19, 25]
(18 ,30) | 0.003 |
T0 vs. T24 T6 vs. T24 | |
| Systolic blood pressurea | Lorazepam |
92 [90, 100] (80, 100) |
92 [90, 90] (80, 100) |
90 [80, 97] (80, 100) |
90 [75, 100] (70, 100) |
90 [77, 92] (70, 100) | 0.647 | - |
| Clonazepam |
90 [90, 100] (80, 110) |
90 [90, 100] (80, 110) |
85 [80, 90] (80, 100) |
85 [80, 85] (70, 90) |
75 [70, 75] (70, 100) | 0.160 | - | |