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Fig. 1 | BMC Pediatrics

Fig. 1

From: Maternal iodine status in a multi-ethnic UK birth cohort: associations with autism spectrum disorder

Fig. 1

Estimated risk of an autism spectrum disorder for children (aged 8 to 12 years) of typical mothers, across a range of maternal I:Cr concentrations (μg/g). Histograms illustrate the distribution of iodine concentrations and although the figures are curtailed at 300 μg/g, the splines (solid line) and 95% CIs (dashed lines) were drawn using data from all participants. Splines were drawn after adjustment for confounders (details in Supplemental Table S4). CIs are particularly wide for very low values of Urinary Iodine/Creatinine. This reflects the very small numbers of women in our sample with extremely low intakes of iodine (only 3·7% of participants have an I:Cr < 35 μg/g) and does not rule out the potential for a more visible trend in more severely deficient populations. The spline position in these figures illustrates the predicted estimate for typical participants (primiparous, white ethnic background, ‘Employed and not materially deprived’, did not smoke, drink or experience complications in pregnancy, of mean age and average BMI

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