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Table 2 Robust General Linear Model with Inverse Probability Weights

From: Contemporary epidemiology of rising atrial septal defect trends across USA 1991–2016: a combined ecological geospatiotemporal and causal inferential study

Parameter

β-Coefficient (95%C.I.)

P-value

Additive Model

 AIAN.Amn

0.73 (0.46, 1)

2.8E-05

 NHCauc.Amn_Cannabis

5.42 (2.42, 8.42)

0.0015

 Analgesics

0.72 (0.21, 1.23)

0.0100

 Asian_Cannabis

1 (0.24, 1.76)

0.0160

 NHAfrc.Amn_Cannabis

−4.55 (−7.53, −1.57)

0.0060

 Alcohol

−34.96 (−49.93, − 19.99)

0.0001

 NHPI_Cannabis

− 0.3 (− 0.42, − 0.18)

9.0E-05

 Cauc.Amn

− 2.89 (− 3.91, − 1.87)

8.9E-06

 Hispanic_Cannabis

− 1.18 (− 1.59, − 0.77)

5.6E-06

 Afrc.Amn

− 0.82 (− 1.09, − 0.55)

4.4E-06

Interactive Models

Four-Way Interaction Amongst Drugs: Tobacco * Alcohol * Cannabis * Analgesics

  Cannabis

913.3 (597.54, 1229.06)

5.8E-05

  Analgesics

842 (549.57, 1134.43)

6.1E-05

  Cannabis: Analgesics

294.1 (188.73, 399.47)

8.3E-05

  Cigarettes: Alcohol

114,400 (68,496.8, 160,303.2)

0.0002

  NHCauc.Amn_Cannabis

5.68 (3.37, 7.99)

0.0003

  Cigarettes: Alcohol: Cannabis

40,180 (23,672.88, 56,687.12)

0.0003

  Cigarettes: Alcohol: Analgesics

36,720 (21,412.4, 52,027.6)

0.0003

  Cigarettes: Alcohol: Cannabis: Analgesics

12,870 (7331.04, 18,408.96)

0.0005

  Afrc.Amn

−0.47 (−0.88, −0.06)

0.0440

  Cauc.Amn

−3.03 (−4.95, −1.11)

0.0080

  NHPI_Cannabis

−0.28 (− 0.44, − 0.12)

0.0027

  Hispanic_Cannabis

− 1.99 (− 3.01, − 0.97)

0.0020

  Alcohol: Cannabis: Analgesics

− 3184 (− 4540.71, − 1827.29)

0.0004

  Alcohol: Analgesics

− 9055 (− 12,759.4, − 5350.6)

0.0003

  NHAfrc.Amn_Cannabis

−2.38 (− 3.36, − 1.4)

0.0003

  Alcohol: Cannabis

− 9987 (− 14,012.84, − 5961.16)

0.0003

  Alcohol

− 28,390 (− 39,456.16, − 17,323.84)

0.0002

  Cigarettes: Cannabis: Analgesics

− 1191 (− 1619.85, − 762.15)

8.6E-05

  Cigarettes: Analgesics

− 3418 (− 4618.11, − 2217.89)

6.8E-05

  Cigarettes: Cannabis

− 3686 (− 4975.29, − 2396.71)

6.5E-05

  Cigarettes

−10,550 (− 14,176, − 6924)

5.5E-05

Four-Way Interaction Amongst Ethnic_Cannabis: Cauc.Amn * Afrc.Amn * Asian.Amn * AIAN.Amn

  Asian_Cannabis

78.88 (64.38, 93.38)

1.1E-08

  NHCauc.Amn_Cannabis: Asian_Cannabis

294.32 (235.62, 353.02)

3.5E-08

  NHCauc.Amn_Cannabis

549.56 (436.25, 662.87)

5.5E-08

  NHCauc.Amn_Cannabis: Asian_Cannabis: AIAN.Amn_Cannabis

51.74 (40.9, 62.58)

6.9E-08

  NHAfrc.Amn_Cannabis: AIAN.Amn_Cannabis

51.34 (34.03, 68.65)

2.6E-05

  Cigarettes

9.15 (5.41, 12.89)

0.0002

  NHCauc.Amn_Cannabis: NHAfrc.Amn_Cannabis: Asian_Cannabis

6.72 (2.33, 11.11)

0.0084

  Cocaine

−1.23 (−1.99, −0.47)

0.0060

  Afrc.Amn

−0.59 (− 0.84, − 0.34)

0.0004

  Alcohol

−31.75 (−45.31, − 18.19)

0.0003

  Cauc.Amn

−2.69 (−3.65, − 1.73)

4.5E-05

  AIAN.Amn_Cannabis

−122.94 (− 162.47, − 83.41)

1.6E-05

  NHCauc.Amn_Cannabis: NHAfrc.Amn_Cannabis

−67.25 (−88.59, − 45.91)

1.3E-05

  Asian_Cannabis: AIAN.Amn_Cannabis

−66.75 (− 85.02, − 48.48)

2.3E-06

  NHAfrc.Amn_Cannabis: Asian_Cannabis: AIAN.Amn_Cannabis

−50.24 (−63.74, − 36.74)

1.8E-06

  Hispanic_Cannabis

− 11.55 (− 14.35, − 8.75)

4.8E-07

  NHAfrc.Amn_Cannabis: Asian_Cannabis

− 195.38 (− 233.99, − 156.77)

3.1E-08

  NHAfrc.Amn_Cannabis

− 426.55 (− 505.56, − 347.54)

1.3E-08

  NHCauc.Amn_Cannabis: NHAfrc.Amn_Cannabis: AIAN.Amn_Cannabis

−9.25 (− 10.96, −7.54)

1.2E-08

3 + 3 Way Interactions: Tobacco * Alcohol * Cannabis + Cauc.Amn * AIAN.Amn * Asian.Amn

  Cigarettes: Alcohol

3696.88 (2707.37, 4686.39)

1.5E-07

  Analgesics

1.53 (1.1, 1.96)

4.3E-07

  Cigarettes: Alcohol: Cannabis

1467.06 (997.23, 1936.89)

2.5E-06

  Cannabis

28.63 (18.07, 39.19)

1.9E-05

  AIAN.Amn

0.71 (0.44, 0.98)

5.0E-05

  Cauc.Amn

−2.52 (−4.24, −0.8)

0.0083

  Afrc.Amn

− 0.78 (−1.09, − 0.47)

4.0E-05

  Alcohol: Cannabis

−368.51 (− 503.71, − 233.31)

1.8E-05

  Cigarettes: Cannabis

−113.89 (− 151.25, −76.53)

3.6E-06

  Cigarettes

− 288.27 (− 376.25, − 200.29)

1.2E-06

  Alcohol

− 950.06 (− 1226.77, − 673.35)

5.8E-07