| |
Pre-implementation Period 1 (n = 61)
|
Post-implementation Period 2 (n = 59)
|
P-value
|
|---|
|
Sex
|
|
Female
|
26/61 (43%)
|
27/59 (46%)
|
0.73
|
|
Gestational age, weeks
|
40 (39–40)
|
40 (39–41)
|
0.91
|
|
Gestational days
|
283 (279–286)
|
281 (278–287)
|
0.99
|
|
Birthweight, (grams), mean (SD)
|
3768 (559)
|
3899 (497)
|
0.26
|
|
Arterial cord pH
|
7.20 (7.10–7.24) (n = 54)
|
7.22 (7.13–7.26) (n = 50)
|
0.080
|
|
Apgar score
|
|
5 min < 7
|
6/61 (9.8%)
|
3/59 (5.1%)
|
0.32
|
|
10 min < 7
|
4/61 (6.6%)
|
2/59 (3.4%)
|
0.43
|
|
Rupture of membranes
|
|
0–12 h
|
43/58 (74%)
|
37/53 (70%)
|
0.34
|
|
> 12–24 h
|
10/58 (17%)
|
7/53 (13%)
|
0.48
|
|
> 24 h-1 week
|
5/58 (8.6%)
|
9/53 (17%)
|
0.23
|
|
CRP mg/L
|
52 (37–62)
|
42 (31–56)
|
0.10
|
|
IL-6 ng/L
|
444 (152–1441) (n = 53)
|
322 (127–1470) (n = 54)
|
0.61
|
- Term infants treated for early-onset sepsis (EOS) pre- and post-implementation of new antibiotic treatment guidelines. Period 1 and 2 include term infants with culture-negative sepsis who met the criteria of the guidelines. Data are median (IQR) or n/total (%) except for birthweight which is mean (SD). Numbers are less than n in each group where data were not available. CRP C-reactive protein, IL-6 Interleukin-6
