From: A modified Delphi to define drug dosing errors in pediatric critical care
Drug Class and Patient characteristics | Threshold for dosing error below reference range (% consensus) | Threshold for dosing error Above reference range (% consensus) |
---|---|---|
NEPHROTOXIC ANTIBIOTIC (e.g. Gentamicin, Vancomycin) | ||
In a patient with normal renal functiona | 10% (81) | 10% (79) |
In a patient with acute renal failureb | 10% (76) | 10% (74) |
NON-TOXIC ANTIBIOTIC (e.g. Ampicillin)a | ||
In stable patient, no organ dysfunction | 10% (68) | Partial agreementc |
HEPATOTOXIC MEDICATION (e.g. Acetaminophen) | ||
In patient with normal hepatic function | 10% (74) | 10% (76) |
In a patient with acute hepatic failure | 10% (76) | 10% (74) |
OPIOID (e.g Morphine) | ||
In an opioid naïve patient with normal organ function | 10% (66) | 10% (71) |
In a patient with an opioid tolerance | 10% (63) | Partial agreementd |
In a patient with acute renal failureb | 10% (74) | 10% (79) |
In a patient with a previous opioid related adverse eventh | Partial agreemente | Partial agreemente |
BENZODIAZEPINE (e.g. Lorazepam) | ||
In an opioid naïve patient with normal organ function | 10% (61) | 10% (79) |
In a patient with acute renal failureb | 10% (66) | 10% (84) |
In a patient with a previous opioid related adverse eventh | Partial agreementf | 10% (60) |
ANTICOAGULANT (e.g. Heparin) | ||
In a stable patient, no organ dysfunction | 10% (71) | 10% (73) |
In a patient with a previous heparin-related hemorrhage | Partial agreementg | 1% (71) |
ELECTROLYTE BOLUS (e.g. Potassium chloride) | ||
In stable patient, no organ dysfunction | 10% (66) | Partial agreementi |