Table 2 Principles of dosing error, agreement statement, and proportion of consensus agreement^a for each statement

 Dosing a drug above reference range, but the drug dose was intercepted (near-miss) and did not reach patient

76 Round 1

 Dosing a drug below the minimum recommended dose, when the drug is possibly life-saving

73 Round 2

 Dosing a drug in a dose that is predicted to give serum levels below desired therapeutic range (e.g. 50% below lower limit target)

62 Round 2

 Dosing a drug by weight, without accounting for a significant drug interaction

68 Round 3

 Dosing a drug in a dose that is likely to give serum levels above desired therapeutic range (e.g. 50% above upper limit target)

60 Round 2

 Dosing a drug by weight, without adjusting for age

76 Round 2

 Dosing a drug by weight, without accounting for body surface area

73 Round 1

 Dosing a drug dose above the maximum dose recommended in the hospital formulary, guideline or reference sources

66 Round 2

 Dosing a drug above the maximum recommended dose, in a patient who is in end-of life care

71 Round 2

 Dosing a drug above the maximum recommended dose in a patient who is on ECMO^b

82 Round 2

 Dosing a drug above the maximum recommended dose, when the drug is possibly life-saving (e.g. antibiotics in sepsis)

60 Round 2

 Dosing a drug by weight, without adjusting for renal insufficiency (Creatinine 50% higher than baseline)

69 Round 3

 Dosing a drug dose that cannot easily be administered using dosage forms available

66 Round 2

 None

Dosing a drug at a dose where the patient has had a previous severe adverse event

Partial agreement^c

Dosing a drug for which the use is off-label in children (i.e. prescribed for a condition that it is not officially approved for)

Partial agreement^d