Table 2 Linear regression modelling of cytokine levels at study start (baseline) and stimulated C-peptide (log transformed) at 6 and 12 months
Baseline cytokines association to: | C-peptide at 6 months, adjusted for sex, age, HbA1c and Tanner | C-peptide at 12 months adjusted for sex, age, HbA1c and Tanner | ||
|---|---|---|---|---|
Predictor | Outcome Intercept CI (5–95%) | P-value | Outcome Intercept CI (5–95%) | P-value |
IFN-γ | -0.03 (-0.1; 0) | 0.507 | 0.03 (0; 0.1) | 0.451 |
IL-10 | -0.57 (-1; -0.1) | 0.043 | 0.23 (-0.2; 0.7) | 0.384 |
IL-12p70 | -1.85 (-3.8; 0.1) | 0.122 | -1.23 (-2.7; 0.2) | 0.165 |
IL-2 | -0.66 (-1.8; 0.5) | 0.333 | 0.3 (-0.8; 1.4) | 0.640 |
IL-4 | -10.3 (-19.5; -1.1) | 0.069 | 6.64 (-4.8; 18.1) | 0.328 |
IL-6 | -0.38 (-0.77; 0) | 0.117 | 0.14 (-0.2; 0.5) | 0.514 |
IL-8 | 0.03 (-0.1; 0.2) | 0.620 | -0.05 (-0.2; 0.1) | 0.535 |
TNFα | -0.38 (-0.6; -0.1) | 0.011 | 0 (-0.2; 0.2) | 0.976 |