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Table 1 Clinical characteristics and cytokine concentrations of study population at the time of blood sampling

From: Systemic TNFα correlates with residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes

 

Baseline visit

Visit 6 months

Visit 12 months

 

Mean (SD)

Mean (SD)

Mean (SD)

N (% females)

63 (33)

63 (33)

63 (33)

Age (years)

11.3 (3.3–17.7)

11.8 (3.8–18.2)

12.4 (4.4–18.7)

HbA1c (mmol/mol)

51.73 (11.1)

49 (8)

53.05(13.4)

C-peptide, fasting (pmol/L)

194.89 (118.5)

172.46 (114.7)

148.95 (121.4)

C-peptide, stimulated*

(pmol/L)

685.54 (377.5)@#

518.3 (364.3)

446.59 (377.5)

BMI (kg/m2)

17.96 (2.8)

18.43 (3)

18.75 (3.1)

BMI-SDS

-0.03 (1)

0.07 (1)

0.07 (1)

IFN-γ (pg/mL)

1.87 (2.05)

2.15 (5.08)

2.36 (5.2)

IL-10 (pg/mL)

0.63 (0.3)

0.56 (0.2)

0.57 (0.3)

IL-12p70 (pg/mL)

0.15 (0.1)

0.13 (0.1)

0.14 (0.1)

IL-2 (pg/mL)

0.12 (0.2)

0.1 (0.1)

0.09 (0.1)

IL-4 (pg/mL)

0.05 (0.0)

0.04 (0.0)

0.04 (0.0)

IL-6 (pg/mL)

0.42 (0.4)

0.4 (0.3)

0.36 (0.3)

IL-8 (pg/mL)

4.37 (1.7)

4.03 (0.9)

3.91 (1.1)

TNFα (pg/mL)

3.03 (0.7)

2.92 (0.7)

2.8 (0.8)

  1. Characteristics at time of blood sampling. Data is presented as mean (SD) or mean (range) where indicated. BMI Body mass index, BMI-SDS BMI standard deviation score, HbA1c Haemoglobin A1c. *P < 0.05 in comparison between groups evaluated using ANOVA. @P < 0.05 between baseline and 6 months #P < 0.05 between baseline and 12 months ¤P < 0.05 between 6 months and 12 months