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Table 2 SWYC neurodevelopmental and behavioral outcomes in children with severe and moderate Zika related microcephaly, children exposed without microcephaly and neurotypical controls

From: Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Research Group Cohort

SWYC components Study Groups P Value (Σ2)
Severe
Microcephaly
Moderate microcephaly ZIKV maternal infection a Controls b
(n = 114) (n = 20) (n = 94) (n = 46)
Development milestone (Brazil), No. (%)
  “At risk”/Needs review 113 (99.1)c 13 (65.0)c 13 (13.8) 10 (21.7) < 0.001
  “Appears to Meet Age Expectations” 1 (0.9) 7 (35.0) 81 (86.2) 36 (78.3)
Development milestone (USA), No. (%)
  “At risk”/Needs review 114 (100.0)c 14 (70.0)c 19 (20.2) 12 (26.1) < 0.001
  “Appears to Meet Age Expectations” 0 (0.0) 6 (30.0) 75 (78.8) 34 (73.9)
Baby and Preschool Pediatric
Symptoms Checklist, No. (%)
  “At risk”/Needs further evaluation or investigation 55 (51.0) 13 (65.0) 40 (42.5) 28 (63.7) 0.70
  Adequate 53 (49.0) 7 (35.0) 54 (57.5) 16 (36.3)
  Missing 6 0 0 2  
  1. aNormocephalic children born to mothers ZIKV PCR+
  2. bNormocephalic children, considered neurotypical controls
  3. cCells making the greatest contribution to significant results
  4. Σ2test for trend: 151.6 (p < 0.0000001) OR: 1 (controls); 0.58 (ZIKV maternal infection); 6.69 (moderate microcephaly); 406.8 (severe microcephaly)
  5. Σ2test for trend: 138.2 (p < 0.0000001) OR: 1 (controls); 0.72 (ZIKV maternal infection); 6.61 (moderate microcephaly); not calculated (severe microcephaly)