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Table 3 Meta-analysis between MTHFR C677T polymorphism and ASD risk under genetic models

From: Association between MTHFR C677T/A1298C and susceptibility to autism spectrum disorders: a meta-analysis

Genetic Models Fixed/ Random effect
OR(95%CI)
Heterogeneity
P
I2(%) Publication Bias P of Egger’s/Begg test
Allele Contrast (T vs C) 1.63 (1.30–2.05)b* 0.000 84.3 0.029/0.017
 Mandatory fortification with folate
  Yes 1.32 (1.00–1.75)b 0.000 86.2 0.441/0.707
  No 2.08 (1.40–3.08)b* 0.000 84.4 0.044/0.032
 Population
  Asian 1.95 (1.14–3.33)b* 0.000 90.3 0.178/0.221
  Caucasian 1.51 (1.17–1.95)b* 0.000 81.5 0.130/0.087
 Sample source
  Hospital-based 2.10 (1.34–3.14)b* 0.000 89.6 0.062/0.174
  Population-based 1.33 (1.11–1.65)b* 0.006 64.3 0.267/0.386
 HWE
  Yes 1.46 (1.18–1.81)b* 0.000 76.0 0.005/0.006
  No 2.17 (1.52–3.10)b* 0.030 71.4 0.779/1.000
Heterozygote (CT vs CC) 1.66 (1.31–2.11)b* 0.000 69.2 0.017/0.008
 Mandatory fortification with folate     
  Yes 1.45 (1.05–2.00)b* 0.001 76.1 0.784/0.707
  No 1.95 (1.34–2.82)b* 0.002 66.4 0.031/0.020
 Population
  Asian 1.80 (1.15–2.80)b* 0.005 72.7 0.044/0.221
  Caucasian 1.62 (1.20–2.18)b* 0.000 70.4 0.098/0.029
 Sample source
  Hospital-based 2.23 (1.48–3.35)b* 0.000 76.3 0.048/0.108
  Population-based 1.26 (1.07–1.48)a* 0.249 22.6 0.191/0.266
 HWE
  Yes 1.49 (1.18–1.87)b* 0.005 57.9 0.007/0.009
  No 2.24 (1.40–3.58)b* 0.064 63.6 0.001/0.296
Homozygote (TT vs CC) 2.03 (1.33–3.09)b* 0.000 74.6 0.048/0.053
 Mandatory fortification with folate     
  Yes 1.66 (0.94–2.94)b 0.000 84.7 0.355/0.700
  No 2.78 (1.35–5.73)b* 0.001 66.5 0.044/0.074
 Population
  Asian 2.45 (0.95–6.31)b 0.000 81.2 0.286/0.806
  Caucasian 1.92 (1.16–3.16)b* 0.000 73.7 0.147/0.119
 Sample source
  Hospital-based 2.54 (1.26–5.16)b* 0.000 82.5 0.142/0.536
  Population-based 1.61 (1.01–2.58)b* 0.031 54.7 0.122/0.266
 HWE
  Yes 1.50 (1.05–2.13)b* 0.012 53.4 0.006/0.012
  No 4.72 (3.26–6.84)a* 0.988 0.0 0.291/1.000
Dominant (TT + CT vs CC) 1.82 (1.39–2.37)b* 0.000 78.6 0.021/0.010
 Mandatory fortification with folate
  Yes 1.49 (1.04–2.15)b* 0.000 83.3 0.775/0.707
  No 2.22 (1.46–3.36)b* 0.000 76.3 0.051/0.049
 Population
  Asian 2.03 (1.21–3.42)b* 0.000 82.7 0.164/0.221
  Caucasian 1.73 (1.25–2.41)b* 0.000 78.4 0.089/0.029
 Sample source
  Hospital-based 2.51 (1.57–4.02)b* 0.000 84.6 0.050/0.108
  Population-based 1.32 (1.13–1.54)a* 0.066 47.2 0.253/0.266
 HWE
  Yes 1.59 (1.23–2.04)b* 0.000 68.3 0.008/0.003
  No 2.59 (1.60–4.18)b* 0.038 69.5 0.016/0.296
Recessive (TT vs CT + CC) 1.59 (1.14–2.22)b* 0.000 65.6 0.033/0.053
 Mandatory fortification with folate
  Yes 1.37 (0.93–2.00)b 0.003 72.3 0.114/0.707
  No 2.23 (1.13–4.38)b* 0.002 65.1 0.039/0.283
 Population
  Asian 2.07 (0.84–5.10)b* 0.000 81.5 0.243/0.806
  Caucasian 1.47 (1.04–2.07)b* 0.015 54.7 0.138/0.087
 Sample source
  Hospital-based 1.76 (1.02–3.04)b* 0.000 76.0 0.155/0.386
  Population-based 1.41 (1.11–1.80)a* 0.057 48.9 0.122/0.266
 HWE
  Yes 1.23 (1.02–1.48)a* 0.025 48.7 0.006/0.033
  No 2.79 (2.05–3.80)a* 0.459 0.0 0.489/1.000
  1. *:P < 0.05
  2. aFixed effect
  3. bRandom effect