Summary of findings: | ||||||
3% Hypertonic Saline compared to 0.9% Normal Saline for ped bronchitis | ||||||
Patient or population: ped bronchitis Setting: Intervention: 3% Hypertonic Saline Comparison: 0.9% Normal Saline | ||||||
Outcomes | Anticipated absolute effects* (95% CI) | Relative effect(95% CI) | № of participants (studies) | Certainty of the evidence(GRADE) | Comments | |
Risk with 0.9% Normal Saline | Risk with 3% Hypertonic Saline | |||||
CSS | The mean CSS was −3.57 to 8.8 point | MD 0.93 point lower(1.23 lower to 0.62 lower) | – | 2010(11 RCTs) | ⨁⨁◯◯LOW a,b | |
RDAI | The mean RDAI was −4.7 to 5.32 point | MD 0.6 point lower(0.95 lower to 0.26 lower) | – | 1369(5 RCTs) | ⨁⨁⨁◯MODERATE a | |
LOS | The mean LOS was 1.4 to 7.49 days | MD 0.54 days lower(0.86 lower to 0.23 lower) | – | 2055(20 RCTs) | ⨁⨁◯◯LOW a,b | |
Rate of hospitalisation | 402 per 1000 | 342 per 1000(298 to 394) | RR 0.85(0.74 to 0.98) | 1710(8 RCTs) | ⨁⨁⨁◯MODERATE a | |
Rate of re-admission | 135 per 1000 | 97 per 1000(53 to 180) | RR 0.72(0.39 to 1.33) | 485(4 RCTs) | ⨁⨁⨁◯MODERATE a | |
Time of sleeping | The mean time of sleeping was 4.54 to 7.32 h | MD 1.72 h higher(0.43 lower to 3.88 higher) | – | 110(2 RCTs) | ⨁⨁◯◯LOW a,b | |
Frequency of wake-up in the night | The mean frequency of wake-up in the night was 3.11 to 9.28 time | MD 5.61 time lower(6.54 lower to 4.67 lower) | – | 110(2 RCTs) | ⨁⨁⨁◯MODERATE a |