Fig. 1
From: Fatal central nervous system co-infection with SARS-CoV-2 and tuberculosis in a healthy child
Selected sequential MRI/MRA images. a Diffusion-weighted image shows a 7 mm area of restriction diffusion in the left anterior frontal lobe subcortical white matter (arrow), day 12 of illness; b T1-weighted image with gadolinium showing mild leptomeningeal enhancement along the tentorium, day 12; c Diffusion-weighted image showing no restriction diffusion in the left anterior frontal lobe subcortical white matter, day 16; d T2 FLAIR shows abnormal increased signal mainly involving the midbrain, bilateral deep frontal, and bilateral medial temporal areas, day 16; e 3-D time of flight MRA shows a normal circle of Willis, day 16; f T1-weighted image with gadolinium showing diffuse leptomeningeal enhancement, day 16; g T2 FLAIR showing extensive grey matter lesions involving the deep frontal lobe, temporal lobe, midbrain, and cerebellar vermis, with no obvious cerebellar involvement, day 30; h 3-D time of flight MRA showing no flow in intracranial vessels with flow in extracranial vessels, day 30