Comparison of child and family reports of health-related quality of life in pediatric acute lymphoblastic leukemia patients after induction therapy

Nakajima, Shohei; Sato, Iori; Soejima, Takafumi; Koh, Katsuyoshi; Kato, Motohiro; Okamoto, Yasuhiro; Imamura, Toshihiko; Maeda, Miho; Ishida, Yasushi; Manabe, Atsushi; Kamibeppu, Kiyoko

doi:10.1186/s12887-020-02287-3

Table 2 Agreement of child self-reports and family proxy-reports of pediatric health-related quality of life (N = 522)

From: Comparison of child and family reports of health-related quality of life in pediatric acute lymphoblastic leukemia patients after induction therapy

		n	Child self-reports		Family proxy-reports		Diffences^a)	t-value^b)	95% CI for Differences (lower) (upper)		ICC^C)	95% CI for ICC (lower) (upper)
PedsQL-G (Generic Core Scales)
Physical functioning	All Children	518	54.4	± 25.5	45.0	± 26.2	9.3	9.64	7.4	11.2	.60	.47	.70
	Young Child	204	56.9	± 24.5	47.4	± 27.3	9.3	6.08	6.3	12.3	.61	.45	.72
	School age	212	53.0	± 26.9	44.7	± 26.4	8.2	5.18	5.1	11.3	.60	.47	.70
	Adolescent	102	52.7	± 24.1	41.1	± 23.1	11.6	5.88	7.7	15.6	.58	.30	.73
Emotional functioning	All Children	518	68.6	± 26.1	63.2	± 24.9	5.4	4.84	3.2	7.6	.49	.42	.56
	Young Child	204	64.3	± 27.2	65.8	± 25.4	−1.3	−0.71	−5.1	2.4	.48	.36	.58
	School age	212	72.2	± 24.9	62.1	± 25.7	10.0	5.98	6.7	13.3	.50	.35	.62
	Adolescent	102	69.9	± 25.1	60.5	± 21.6	9.4	4.39	5.1	13.6	.54	.34	.68
Social functioning	All Children	494	84.5	± 18.3	82.0	± 21.4	2.7	2.76	0.8	4.6	.41	.33	.48
	Young Child	193	81.8	± 18.2	82.7	± 21.0	−0.8	−0.51	−3.9	2.3	.40	.28	.51
	School age	209	86.8	± 17.9	80.6	± 22.4	6.3	4.37	3.4	9.1	.46	.34	.57
	Adolescent	92	85.4	± 18.5	83.8	± 20.2	1.9	0.80	−2.8	6.6	.32	.12	.49
School functioning	All Children	391	75.1	± 27.2	74.5	± 26.0	1.3	1.02	−1.2	3.7	.55	.48	.61
	Young Child	119	63.8	± 31.0	78.1	± 25.4	−12.2	−5.45	− 16.7	−7.8	.56	.35	.71
	School age	196	82.7	± 21.9	75.0	± 25.7	7.2	4.61	4.1	10.3	.54	.41	.65
	Adolescent	76	74.4	± 26.6	66.6	± 21.6	7.2	2.60	1.7	12.7	.57	.40	.71
PedsQL-C (Cancer Module)
Pain and hurt	All Children	521	74.6	± 31.3	71.1	± 29.9	3.5	2.87	1.1	5.9	.59	.53	.64
	Young Child	204	72.8	± 32.8	74.7	± 28.5	−1.9	−0.97	−5.8	2.0	.59	.49	.67
	School age	215	77.7	± 30.2	70.4	± 31.2	7.3	3.79	3.5	11.1	.56	.45	.65
	Adolescent	102	71.5	± 30.0	65.3	± 28.8	6.1	2.62	1.5	10.8	.67	.54	.76
Nausea	All Children	520	65.6	± 28.3	69.4	± 28.3	−3.7	−3.80	−5.5	−1.8	.70	.65	.74
	Young Child	203	61.8	± 26.9	76.0	± 24.7	−14.0	−10.04	− 16.8	− 11.3	.61	.28	.78
	School age	215	71.0	± 28.6	67.3	± 30.4	3.6	2.68	1.0	6.3	.77	.71	.82
	Adolescent	102	62.0	± 29.1	60.4	± 27.8	1.6	0.73	−2.7	5.9	.70	.59	.79
Procedural anxiety	All Children	520	63.9	± 32.2	69.5	± 30.0	−5.6	−4.99	−7.8	−3.4	.65	.59	.71
	Young Child	205	50.9	± 30.7	64.1	± 30.9	−13.2	−7.45	−16.7	−9.7	.61	.40	.73
	School age	214	69.5	± 32.3	70.2	± 30.4	−0.6	−0.37	− 4.0	2.7	.69	.61	.76
	Adolescent	101	78.4	± 24.4	78.9	± 24.3	− 0.6	−0.25	−5.2	4.1	.53	.38	.66
Treatment anxiety	All Children	509	86.3	± 22.5	85.6	± 21.3	0.6	0.65	−1.2	2.3	.58	.52	.64
	Young Child	199	82.6	± 25.7	84.3	± 22.4	−2.1	−1.39	−5.0	0.9	.62	.53	.70
	School age	212	87.6	± 21.3	86.3	± 20.6	1.3	0.98	−1.3	3.9	.58	.48	.66
	Adolescent	98	91.0	± 16.4	86.8	± 20.5	4.3	2.26	0.5	8.1	.48	.31	.61
Worry	All Children	515	65.6	± 30.4	66.3	± 31.7	−0.5	−0.33	−3.7	2.6	.32	.24	.40
	Young Child	200	64.8	± 32.6	75.7	± 29.7	−11.1	−4.12	−16.4	−5.8	.24	.10	.36
	School age	214	69.4	± 28.0	64.6	± 31.3	5.0	2.14	0.4	9.5	.34	.22	.45
	Adolescent	101	59.2	± 30.0	51.0	± 30.3	8.7	2.80	2.5	15.0	.44	.27	.58
Cognitive problems	All Children	508	75.6	± 23.7	79.4	±22.5	−3.9	−3.92	−5.8	−1.9	.53	.46	.59
	Young Child	199	74.1	± 28.0	83.6	± 19.7	−9.6	−6.04	−12.7	−6.5	.43	.26	.56
	School age	212	78.1	± 26.3	78.5	± 22.2	−0.5	−0.34	−3.1	2.2	.64	.55	.71
	Adolescent	96	73.3	± 30.9	72.4	± 24.7	0.5	0.20	−4.5	5.5	.50	.33	.63
Perceived physical appearance	All Children	488	73.1	± 27.9	74.2	± 27.6	−1.3	−0.98	−3.8	1.3	.48	.40	.54
	Young Child	203	71.1	± 28.0	81.7	± 23.1	−10.6	−5.70	− 14.3	−7.0	.43	.28	.55
	School age	197	75.8	± 26.3	70.1	± 29.6	6.0	3.28	2.4	9.7	.57	.46	.66
	Adolescent	88	71.6	± 30.9	66.6	± 28.4	4.0	1.13	−3.0	10.9	.41	.22	.57
Communication	All Children	483	63.4	± 30.7	63.6	± 29.0	−1.0	−0.78	−3.4	1.5	.58	.52	.64
	Young Child	197	55.8	± 31.1	63.9	± 29.2	−7.8	−4.08	−11.5	−4.0	.58	.48	.68
	School age	198	65.8	± 29.2	60.7	± 30.3	4.6	2.49	1.0	8.3	.61	.51	.69
	Adolescent	88	73.8	± 29.6	69.7	± 24.5	1.7	0.55	−4.3	7.7	.48	.30	.62

Notes: Excluding missing values. Bold scores indicated significantly higher than another reports.
^aMean of the differences subtracting family proxy-reports from child self-reports, ^bComparing children self-reports and family proxy-reports using paired t-test
Abbreviations: CI Confidence interval, ICC Intraclass correlation coefficient, PedsQL Pediatric Quality of Life Inventory™, SD Standard deviation

Back to article page

ISSN: 1471-2431

Contact us

Submission enquiries: bmcpediatrics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Pediatrics

Contact us