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Table 2 Comparison of incidence rates of acute events and morbidity indicators in patients who presented before (early) or after 5 months of age (late) to the Sickle Cell Unit in Jamaica (N = 290)

From: The risk of acute events among patients with sickle cell disease in relation to early or late initiation of care at a specialist center: evidence from a retrospective cohort study

Acute Events
And morbidity indicators
Early Presenters Late Presenters Test Statistics
Events with Incident rates (events/1000 person-year) per group    
 VOC (n = 880) 700 1000 IRR = 1.43; p < 0.001 95% CI(1.18–1.72)
 ACS (n = 571) 570 800 IRR = 1.40; p = 0.002 95% CI (1.12–1.75)
 ASS (n = 112) 280 340 IRR = 1.21; p = 0.38795% CI (0.76–1.89)
 Infection (n = 21) 50 50 IRR = 0.93; p = 0.923 95% CI (0.24–3.08)
Other indicators of morbidity (%) of patients per group (number of patients)    
 Number of patients splenectomised 8 (7%) 12 (7%) χ2 = 0.1 ; p = 0.950
 Hospital admissions/Total visits 330 (48%) 430( 51%) χ2 = 0.8 ; p = 0.364
 Number Ever needing strong opioid for VOC/Total VOC episodes 48 (14%) 97 (21%) χ2 = 5.1 ; p = 0.077
 Number Ever requiring ICU admissions/Total visits 0 3 (0.4%) χ2 = 3.7 ; p = 0.161
 Number of patients needing Oxygen for ACS/Total ACS visits 59 (52%) 81( 56%) χ2 = 0.4 ; p = 0.519
 Transfusions for ASS/Total ASS visits 21 (36%) 15( 28%) χ2 = 1.0 ; p = 0.308
  1. IRR Incidence Rate Ratio
  2. Sepsis (n = 09) accounted for 53% of confirmed cases of infection recorded. The frequency of meningitis (n = 04) and osteomyelitis (n = 04) were equal. The organisms implicated included were pneumococcus (n = 01) which occurred in the late group only, Salmonella (n = 03) and other organisms (n = 07). Of note there were no cases of haemophilus influenza Type B infection