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Table 2 Comparison of incidence rates of acute events and morbidity indicators in patients who presented before (early) or after 5 months of age (late) to the Sickle Cell Unit in Jamaica (N = 290)

From: The risk of acute events among patients with sickle cell disease in relation to early or late initiation of care at a specialist center: evidence from a retrospective cohort study

Acute Events

And morbidity indicators

Early Presenters Late Presenters Test Statistics

Events with Incident rates (events/1000 person-year) per group

   

 VOC (n = 880)

700

1000

IRR = 1.43; p < 0.001 95% CI(1.18–1.72)

 ACS (n = 571)

570

800

IRR = 1.40; p = 0.002 95% CI (1.12–1.75)

 ASS (n = 112)

280

340

IRR = 1.21; p = 0.38795% CI (0.76–1.89)

 Infection (n = 21)

50

50

IRR = 0.93; p = 0.923 95% CI (0.24–3.08)

Other indicators of morbidity (%) of patients per group (number of patients)

   

 Number of patients splenectomised

8 (7%)

12 (7%)

χ2 = 0.1 ; p = 0.950

 Hospital admissions/Total visits

330 (48%)

430( 51%)

χ2 = 0.8 ; p = 0.364

 Number Ever needing strong opioid for VOC/Total VOC episodes

48 (14%)

97 (21%)

χ2 = 5.1 ; p = 0.077

 Number Ever requiring ICU admissions/Total visits

0

3 (0.4%)

χ2 = 3.7 ; p = 0.161

 Number of patients needing Oxygen for ACS/Total ACS visits

59 (52%)

81( 56%)

χ2 = 0.4 ; p = 0.519

 Transfusions for ASS/Total ASS visits

21 (36%)

15( 28%)

χ2 = 1.0 ; p = 0.308

  1. IRR Incidence Rate Ratio
  2. Sepsis (n = 09) accounted for 53% of confirmed cases of infection recorded. The frequency of meningitis (n = 04) and osteomyelitis (n = 04) were equal. The organisms implicated included were pneumococcus (n = 01) which occurred in the late group only, Salmonella (n = 03) and other organisms (n = 07). Of note there were no cases of haemophilus influenza Type B infection