Table 3 Differences between Gitelman syndrome and classic Bartter syndrome
From: Early onset children’s Gitelman syndrome with severe hypokalaemia: a case report
Gitelman syndrome | Bartter syndrome | |
|---|---|---|
Time | Adolescent or adult | Childhood |
Hypokalaemia | yes | yes |
Hypochloric metabolic alkalosis | yes | yes |
High renin activity | yes | yes |
Hypomagnesemia | yes | no |
Urinary calcium | low | low, normal or hypercalciuria |
Development retardation | rare | yes |
Location | renal distal tubule | medullary thick ascending limb |
Gene mutation | SLC12A3 | CLCNKB |