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Table 3 Differences between Gitelman syndrome and classic Bartter syndrome

From: Early onset children’s Gitelman syndrome with severe hypokalaemia: a case report

  Gitelman syndrome Bartter syndrome
Time Adolescent or adult Childhood
Hypokalaemia yes yes
Hypochloric metabolic alkalosis yes yes
High renin activity yes yes
Hypomagnesemia yes no
Urinary calcium low low, normal or hypercalciuria
Development retardation rare yes
Location renal distal tubule medullary thick ascending limb
Gene mutation SLC12A3 CLCNKB