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Table 1 Clinical features of neonates and paired older siblings with hand, foot, and mouth disease

From: Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai

Clinical features
N (%)
Neonates
(N = 16)
Older siblings
(N = 16)
Odds ratio P-value
Fever (temperature ≥ 39 °C) 0 14 (87.5) 0 (0.0, 0.1) *b <  0.01*a
Vomiting 2 (12.5) 10 (62.5) 0.2 (0.1, 0.8) * <  0.01*
Seizure 0 0 1.0 (0.1, 7.3) b 0.50
Symptoms of hypoperfusion 0 1 (6.3) 0 (0.0, 19.0) b 0.50 a
Lethargy 0 2 (12.5) 0 (0.0, 3.4) b 0.24
Cutaneous areas affected
 Perinasal 4 (25.0) 3 (18.8) 1.4 (0.2, 9.1) 0.69
 Perioral 13 (81.3) 14 (87.5) 0.9 (0.7, 1.3) 0.33
 Scalp 0 0 1.0 (0.1, 7.3) b 0.50
 Palms/soles 6 (37.5) 13 (81.3) 0.4 (0.2, 0.8) * 0.02
 Lower limbs 2 (12.5) 9 (56.3) 0.3 (0.1, 1.0) * 0.01
 Upper limbs 14 (87.5) 13 (81.3) 1.3 (0.4, 4.0) 0.66
 Abdomen 0 1 (6.3) 0 (0.0, 19.0) b 0.50 a
 Intraoral erosions 10 (62.5) 16 (100.0) 0.4 (0.2, 0.6) * <  0.01*
Onychomadesis 0 5 (31.3) 0 (0.0, 0.7) * 0.02
Complications 0 1 (6.3) 0 (0.0, 19.0) b 0.50 a
  1. a Two-tailed exact P-value
  2. b Conditional maximum likelihood estimate of odds ratio
  3. * Statistical significance