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Table 3 Comparison of Dubin Johnson syndrome and other causes of neonatal cholestasis

From: Mutation spectrum and biochemical features in infants with neonatal Dubin-Johnson syndrome

  Dubin Johnson syndrome (n = 06) Other causes (n = 129) p value
Male : Female 2 : 4 75 : 54 0.232
Term baby 6 98 0.173
Growth failure 0 21 0.284
Jaundice 6 81 0.125
Hepatomegaly 0 37 0.161
Splenomegaly 0 20 0.342
Acholic stool 2 46 0.908
DB (mg/dL) 7.4 (3.7–11.0) 4.7 (0.8–15.7) 0.036
TB (mg/dL) 11.5 (5.8–15.6) 7.6 (1.3–29.4) 0.026
Cholesterol (mg/dL) 166 (123–246) 154 (23–391) 0.467
AST (IU/L) 27 (25–61) 225 (17-3801) 0.002
ALT (IU/L) 15 (11–40) 143 (3-2493) 0.007
GGT (IU/L) 149 (33–209) 290 (11-1605) 0.265
PT (INR) 1.10 (0.91–1.11) 1.21 (0.77–3.28) 0.255
  1. DB Direct bilirubin; TB Total bilirubin; AST Aspartate aminotransferase; ALT Alanine aminotransferase; GGT Gamma-glutamyl transferase; PT Prothrombin time
  2. The laboratory results ​​are expressed as median (range)