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Table 2 Clinical features and biochemical findings of DJS

From: Mutation spectrum and biochemical features in infants with neonatal Dubin-Johnson syndrome

Patients number Sex Acholic stool DB
(mg/dL)
TB
(mg/dL)
AST
(IU/L)
ALT
(IU/L)
Liver biopsy Variant
1 F - 4.1 5.8 25 14 Intracytoplasmic cholestasis
Extramedullary hematopoiesis
Suspicious bile duct loss
p.Arg768Trp
p.Gly693Glu
2 F - 11.0 15.6 61 15 - c.2439 + 2T > C
p.Tyr119SfsTer34
3 M + 9.4 12.0 28 15 Intracytoplasmic cholestasis
Extramedullary hematopoiesis
p.Arg768Trp
p.Arg768Trp
4 M   7.0 13.4 25 17 - p.Arg100Ter
p.Arg1310Ter
5 F   3.7 8.1 54 40 - p.Thr394Arg
p.Asn718Ser
6 F + 7.7 11.0 26 11 Intracanalicular and intracytoplasmic cholestasis
Suspicious loss of interlobular bile ducts
Degenerative change of interlobular bile ducts
p.Arg100Ter
p.Arg768Trp
  1. The laboratory results are the highest values ​​for the patients