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Table 3 Secondary endpoints

From: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study

 

PSV1

NAVA

PSV2

P

DelayTrinsp(msec)

116 [97–139.5]

27 [22–39]

125 [93–139]

< 0.001

DelayTrexp(msec)

91 [75–186]

45 [15–68]

82 [70–140]

0.013

Timesync(sec)

0.17 [0.13–0.21]

0.41 [0.37–0.51]

0.15 [0.13–0.18]

< 0.001

Timesync/Tineu

0.60 [0.46–0.80]

0.96 [0.93–0.99]

0.67 [0.50–0.74]

< 0.001

Neuroventilatory efficiency index (Vt/∫Edi) (mL × kg PBW/μVs-1)

0.82 [0.33–2.68]

0.51 [0.30–1.60]

0.42 [0.21–0.98]

0.28

Vtneu/Vtmech(%)

100 [83–100]

100 [94–100]

100 [91–100]

0.60

PTPEdi/min (μV/sec/min)

1.21 [0.87–4.63]

1.79 [0.89–3.63]

2.09 [1.23–8.25]

0.48

PTPEdi/breath (μV/sec)

2.75 [2–8.35]

2.83 [2.1–8.04]

3.82 [1.97–13.16]

0.61

PeakPaw (cmH2O)

13.52 [11.29–21.82]

14.65 [12.32–28.20]

17.5 [15–23.35]

0.47

PeakEdi (μVs)

6.63 [4.62–21.51]

16.32 [7.52–25.46]

8.83 [5.19–33.10]

0.78

Mean Arterial Pressure (mmHg)

70 [65–84]

72 [66–78]

67 [63–70]

0.36

HR (bpm)

149 [140–154]

150 [130–154]

147 [137–155]

0.33

PaO2/FiO2ratio

232 [198–284]

288 [224–337]

228 [197–291]

0.004

PaCO2(mmHg)

34 [31–41]

32 [29–42]

32 [28–35]

0.62

pHa

7.44 [7.41–7.46]

7.43 [7.42–7.45]

7.45 [7.43–7.48]

0.50

  1. Data are expressed as median (interquartile range: 25th and 75th percentile)
  2. Abbreviations: DelayTrinsp inspiratory trigger delay, DelayTrexp expiratory trigger delay, Timesync time of synchrony, Edi electrical activity of diaphragm, sec seconds, Vt tidal Volume, ∫Edi Edi time integral, Vtneu neural tidal volume, Vtmech mechanical tidal volume, msec milliseconds, Kg Kilograms, PBW predicted body weight; ml: milliliters, PTPEdi pressure time product of Edi per breaths and per minute, Paw airway pressure, μV microvolt; min: minute, % percentage, bpm beats per minute, HR heart rate, PaO2/FiO2 ratio partial pressure of arterial oxygen to fraction of the inspired oxygen ratio, PaCO2 arterial partial pressure of carbon dioxide, mmHg millimetres of mercury, pHa arterial pH