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Table 4 Risk of Hyperoxemia at potential High SpO2 Alarm Limits by Maturity Category

From: Thresholds for oximetry alarms and target range in the NICU: an observational assessment based on likely oxygen tension and maturity

  95% SpO2 96% SpO2 97% SpO2 98% SpO2 p
PMA < 33
 n 175 154 150 126  
 Risk > 80 (%) 18% (12–23%) 12% (7–18%) 37% (30–45%) 45% (34–54%) < 0.001
 Risk > 99 (%) 7% (3–11%) 4% (1–7%) 14% (8–20%) 25% (18–33%) < 0.001
 PaO2 63 (54–73) 62 (54–73) 71 (60–88) 80 (63–100) < 0.001
PMA 33–36
 n 156 172 190 225  
 Risk > 80 (%) 28% (0.21–0.35) 26% (19–32%) 0.43 (36–50%) 0.61 (54–67%) < 0.001
 Risk > 99 (%) 10% (6–15%) 13% (8–18%) 20% (14–25%) 34% (28–40%) < 0.001
 PaO2 68 (61–81) 70 (62–81) 79 (67–92) 86 (73–108) < 0.001
PMA > 36
 n 959 1156 1483 1729  
 Risk > 80 (%) 28% (25–31%) 42% (39–45%) 56% (53–58%) 70% (68–72%) < 0.001
 Risk > 99 (%) 14% (10–14%) 20% (17–22%) 28% (26–30%) 42% (41–45%) < 0.001
 PaO2 70 (61–83) 76 (65–93) 84 (70–103) 94 (78–124) < 0.001
  1. Severe hyperoxemia defined as > 99 mmHg. Differences in risk evaluated with chi-square test. PaO2 presented as median (IQR) with differences evaluated with Kruskal-Wallis test. PaO2 pairs within each maturity category are also statistically different (p < 0.001) except the difference between 95 and 96% SpO2 in both the < 33 weeks and 33–36 weeks groups