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Table 2 Klotho, FGF19, and FGF21 concentrations in correlation with age, parameters of nutritional status, lipid and glucose profiles, ALT and HOMA-IR

From: Klotho and fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity and their associations with metabolic parameters

 

Klotho

FGF19

FGF21

Age

R = 0.053, p = 0.4848

R = 0.064, p = 0.3996

R = 0.159, p = 0.0360

BMI Z-score

R = 0.188, p = 0.0129

R = -0.206, p = 0.0062

R = 0.111, p = 0.1423

BF%

R = 0.210, p = 0.0055

R = −0.143, p = 0.0600

R = 0.202, p = 0.0020

ALT

R = 0.184, p = 0.0149

R = -0.230, p = 0.0022

R = 0.015, p = 0.8413

TC

R = 0.097, p = 0.1997

R = −0.040, p = 0.5913

R = -0.050, p = 0.5057

HDL-C

R = 0.084, p = 0.2649

R = 0.122, p = 0.1076

R = -0.212, p = 0.0047

LDL-C

R = 0.211, p = 0.0051

R = −0.030, p = 0.6852

R = 0.087, p = 0.2504

TGs

R = -0.014, p = 0.8507

R = −0.201, p = 0.0077

R = 0.187, p = 0.0131

Fasting glucose

R = −0,029, p = 0,7082

R = − 0,096, p = 0,2106

R = − 0,084, p = 0,2726

HOMA-IR

R = 0.129, p = 0.0879

R = − 0.313, p < 0.0001

R = 0.098, p = 0.1978

  1. HOMA-IR Homeostatic Model Assessment of Insulin Resistance, BMI body mass index, BF% body fat [%], TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TGs triglycerides, ALT alanine aminotransferase, FGF19 fibroblast growth factor 19, FGF21 fibroblast growth factor 21