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Table 3 Comparison of patients characteristics according to the alpha thalassemia trait

From: High fetal hemoglobin level is associated with increased risk of cerebral vasculopathy in children with sickle cell disease in Mayotte

 Alpha thalassemia trait (n = 80)No alpha thalassemia trait (n = 52)P
Mean (±SD) or n (%)
Hb (g/d L)8,2 (±0,1)7,7 (±0,2)0,007
Hématocrit (%)25,6 (±0,4)23,8 (±0,5)0,004
MCV (fL)73,3 (±1)81,8 (±1,5)< 0,001
Reticulocytes (G/L)239,6 (±10)288,2 (±13,8)0,004
TCD  0,017
Normal72 (90)37 (71,2) 
Limit3 (3,7)8 (15,4) 
Pathological5 (6,3)7 (13,4) 
Splenomegaly ratio0,54 (±0,03)0,43 (±0,05)0,057
Cerebral vasculopathy  0,004
Yes78 (91,8)43 (72,9) 
Pathological TCD/MRI7 (8,2)13 (22) 
Stroke03 (5,1) 
RBC Transfusion  0,028
No28 (29,4)10 (15,6) 
Occasionnally60 (63,2)42 (65,6) 
Exchange transfusion7 (7,4)12 (18,8)