Skip to main content

Table 2 Univariate and multivariate analysis of parameters affecting OS in non-malignancy associated HLH

From: Treatment outcomes and prognostic factors for non- malignancy associated secondary hemophagocytic lymphohistiocytosis in children

  Univariate analysis Multivariate analysis
Treatment response included Treatment response excluded
5-year OS P HR(95%CI) P HR(95%CI) P
Age < 1 years old 80.0% VS (69.0%) 0.425     
EBV-associated 79.0% VS (67.0%) 0.262     
Hemoglobin < 60 g/L 25.0% VS (77.0%) < 0.001    3.22 (2.01–19.28) 0.002
Platelet < 30 × 10^9/L 36.0% VS (79.0%) < 0.001    2.15 (0.88–5.24) 0.093
ALT > 200 U/L 73.0% VS (71.0%) 0.935     
TG > 2.5 mg/dl 76.0% VS (62.0%) 0.173     
Fibrinogen < 1.5 66.0% VS (80.0%) 0.170     
Ferritin > 10,000 75.0% VS (72.0%) 0.744     
Albumin < 25 g/L 33.0% VS (82.0%) < 0.001    7.71 (3.10–19.19) < 0.001
Dynamic treatment response   0.010   0.010   
Early stable responder 100%   0.00    
Late stable responder 100%   0.00    
Unstable responder 36%   0.21 (0.08–0.52)    
Non-responder 0%   1.0    
  1. Abbreviations: OS overall survival, HLH hemophagocytic lymphohistiocytosis, HR hazard ratio, EBV Epstein-Barr virus, ALT alanine transferase, TG triglyceride