Table 6 Univariate analysis of prognostic factors for survival
Risk Factors | All Patients | Patients with events | ||||
|---|---|---|---|---|---|---|
5-y OS | p | 5-y EFS | p | 3-y OS | p | |
Age at diagnosis | ||||||
  ≤ 1 y or ≥ 10 ys | 80.9% |  | 49.6% |  | 60.0% |  |
 >1–9 ys | 66.1% | 0.617 | 48.4% | 0.809 | 48.9% | 0.633 |
Site of origin | ||||||
 Parameningeal | 56.6% |  | 49.0% |  | 39.3 |  |
 Non-Parameningeal | 81.9% | 0.204 | 46.6% | 0.903 | 65.6 | 0.094 |
Tumor size | ||||||
  ≤ 5 cm | 83.5% |  | 56.0% |  | 79.4% |  |
 >5 cm | 40.3% | < 0.001 | 30.1% | 0.035* | 10.4% | < 0.001 |
Histologic subtype | ||||||
 Embryonal | 74.6% |  | 51.8% |  | 35.8% (5-y OS) |  |
 Alveolar | 65.5% | 0.172 | 46.9% | 0.339 | 36.4% (5-y OS) | 0.203 |
Primary tumor invasiveness | ||||||
 T1 | 95% |  | 49.5% |  | 88.9% |  |
 T2 | 51.4% | 0.013 | 50.0% | 0.583 | 29.6% | 0.006 |
Regional nodal involvement | ||||||
 N0 | 73.6% |  | 51.4% |  | 60.6% |  |
 N1 | 67.8% | 0.330 | 40.8% | 0.498 | 42.3% | 0.481 |
Metastasis | ||||||
 M0 | 75.7% |  | 51.2% |  | 62.0% |  |
 M1 | 22.2% (3-y OS) | < 0.001 | 25.0% (15-m EFS) | 0.097 | 0.0% | 0.005 |
Surgical-pathologic group | ||||||
 Group II | 100% |  | 62.5% |  | 100% |  |
 Group III | 66.8% |  | 48.3% |  | 55.6% |  |
 Group IV | 22.2% (3-y OS) | 0.001# | 25.0% (15-m EFS) | 0.198 | 0.0% | 0.007# |
Initial RT | ||||||
 Yes | 80.3% |  | 63.9% |  | 35.8% |  |
 No | 49.7% | 0.003 | 21.9% (20-m EFS) | < 0.001 | 36.4% | 0.178 |
Salvage RT | ||||||
 Yes | – |  | – |  | 66.0% |  |
 No | – | – | – | – | 31.2% | 0.033 |