| |
Days
|
AA/AG with AR (5 patients)
|
GG with AR (3 patients)
|
AA/AG without AR (7 patients)
|
|---|
|
Dose/kg (mg/kg)
|
day 7
|
0.14 ± 0.01
|
0.11 ± 0.05
|
0.19 ± 0.14
|
|
day 30
|
0.20 ± 0.03*
|
0.09 ± 0.03
|
0.18 ± 0.13
|
|
day 90
|
0.14 ± 0.05*
|
0.08 ± 0.01
|
0.16 ± 0.12
|
|
day 80
|
0.13 ± 0.04*
|
0.06 ± 0.01
|
0.14 ± 0.10
|
|
day 360
|
0.10 ± 0.04
|
0.05 ± 0.02
|
0.13 ± 0.10
|
|
C0/(dose/kg) (ng/ml)/(mg/kg)
|
day 7
|
55.56 ± 20.87
|
175.42 ± 120.49
|
74.92 ± 62.45
|
|
day 30
|
45.81 ± 10.91 *#
|
105.81 ± 47.40
|
92.53 ± 49.62
|
|
day 90
|
63.92 ± 26.57*#
|
126.11 ± 54.57
|
110.56 ± 55.25
|
|
day 180
|
55.33 ± 23.42*
|
134.14 ± 77.98
|
79.78 ± 35.21
|
|
day 360
|
79.48 ± 49.34
|
121.85 ± 50.87
|
66.35 ± 37.25
|
- Data are expressed as mean ± s.d. Mann Whitney was used as statistical test
- * p-value < 0.05 AA/AG vs GG patients with acute rejections
- # p-value < 0.05 AA/Ag with acute rejection vs AA/AG without acute rejection
