Skip to main content

Table 6 Tacrolimus pharmacokinetic data and occurrence of acute rejection (AR) in the 49 patients of the study

From: CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant

  Days No AR (41 patients) AR (8 patients)
Dose/kg (mg/kg) day 7 0.17 ± 0.08 0.13 ± 0.03
day 30 0.15 ± 0.08 0.15 ± 0.06
day 90 0.11 ± 0.08 0.11 ± 0.08
day 80 0.09 ± 0.07 0.10 ± 0.04
day 360 0.07 ± 0.06 0.08 ± 0.04
C0/(dose/kg) (ng/ml)/(mg/kg) day 7 78.07 ± 45.55 100.51 ± 89.31
day 30 115.22 ± 86.70 72.48 ± 42.91
day 90 115.37 ± 97.21 91.56 ± 49.57
day 180 130.45 ± 102.76 90.36 ± 64.71
day 360 190.11 ± 196.61 98.31 ± 51.3
  1. Data are expressed as mean ± s.d. Mann Whitney was used as statistical test