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Table 2 Thyroid hormonal levels within the normal range, incidences of thyroid dysfunction, and rates of treatment and follow-up in the SGA and AGA groups

From: Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns

 SGA(n = 189)AGA(n = 661)P-value
Thyroid hormone levels within the normal rangec
 TSH (mU/L)a3.74 (2.28 ~ 6.18)3.01 (1.81 ~ 5.41)0.018
 FT4 (pmol/L)b17.76 ± 3.9417.42 ± 3.710.371
 FT3 (pmol/L)3.57 ± 0.733.51 ± 0.690.362
Thyroid dysfunction determined by TFTs
 Transient Hypothyroidism4 (2.12)10 (1.51)0.565
 Transient Hypothyroxinemia22 (11.64)83 (12.56)0.576
 TH with dTSHed3 (1.59)2 (0.30)0.005
 Hyperthyrotropinemia21 (11.11)59 (8.93)0.331
 Low T3 syndrome9 (4.76)37 (5.60)0.413
Treatment and follow-up
 L-T4 treatment55 (29.10)137 (20.73)0.015
 Follow-up months
  0 ~ 6 m44 (23.28)96 (14.75)0.004
  7 ~ 12 m5 (2.65)16 (2.46)0.861
  13 ~ 18 m1 (0.53)4 (0.61)0.904
   > 18 m4 (2.12)9 (1.38)0.456
  1. a Presented as median (interquartile range)
  2. b Presented as mean ± standard deviation
  3. c Normal range: TSH 1.3 ~ 9.91 mU/L for male, 0.77 ~ 19.42 mU/L for female; FT4 11.85 ~ 33.81 pmol/L; FT3 2.63 ~ 5.70 pmol/L
  4. d TH with dTSHe: Transient hypothyroxinemia with delayed TSH elevation